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Table 1 Growth inhibitory activity of Hsp90 inhibitors against Plasmodium falciparum

From: Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors

   3D7 W2
IC50 (nM) CI 95% IC90 (nM) IC50 (nM) CI 95% IC90 (nM)
CQ * 37.9 35.7–40.0 67.2 128.7 118.4–138.9 389.7
DHA * 1.2 1.1–1.3 5.2 0.5 0.4–0.6 1.8
Ansamycin
 Geldanamycin   214.8 180.1–249.5 1700.0 200.2 153.3–247.1 2625.3
 17-DMAG * 118.1 109.4–126.7 286.6 169.5 153.3–185.7 541.9
 17-AAG * 387.5 277.7–497.4 8843.3 161.3 100.1–222.4 9569.7
Resorcinol
 AT13387   665.0 577.2–752.9 4570.9 530.7 418.2–643.3 5369.2
 NVP-AUY922   75.5 67.2–83.7 646.1 75.4 64.7–86.0 460.2
 STA-9090   1254 982.7–1525 4110.6 1294 488.1–2101 >10.000
Benzamides
 SNX-5422   2136 161.9–2661 4322.6 2008 1155–2860 6648.4
 SNX-2112 * 665.0 577.2–752.9 4570.9 1702 697.4–2707 >10.000
Purines
 PUH71   3920 3410–4430 >10.000 4420 3930–4910 >10.000
 PUWS13 * 7000 6180–7820 >10.000 3880 3400–4360 9060
  1. IC50 and IC90 values and their confidence interval (CI) at 95% confidence level are presented
  2. * Significant differences between strains (two-tailed, t test P < 0.05)