Table 1 Growth inhibitory activity of Hsp90 inhibitors against Plasmodium falciparum
From: Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors
| Â | Â | 3D7 | W2 | ||||
|---|---|---|---|---|---|---|---|
IC50 (nM) | CI 95% | IC90 (nM) | IC50 (nM) | CI 95% | IC90 (nM) | ||
CQ | * | 37.9 | 35.7–40.0 | 67.2 | 128.7 | 118.4–138.9 | 389.7 |
DHA | * | 1.2 | 1.1–1.3 | 5.2 | 0.5 | 0.4–0.6 | 1.8 |
Ansamycin | |||||||
 Geldanamycin |  | 214.8 | 180.1–249.5 | 1700.0 | 200.2 | 153.3–247.1 | 2625.3 |
 17-DMAG | * | 118.1 | 109.4–126.7 | 286.6 | 169.5 | 153.3–185.7 | 541.9 |
 17-AAG | * | 387.5 | 277.7–497.4 | 8843.3 | 161.3 | 100.1–222.4 | 9569.7 |
Resorcinol | |||||||
 AT13387 |  | 665.0 | 577.2–752.9 | 4570.9 | 530.7 | 418.2–643.3 | 5369.2 |
 NVP-AUY922 |  | 75.5 | 67.2–83.7 | 646.1 | 75.4 | 64.7–86.0 | 460.2 |
 STA-9090 |  | 1254 | 982.7–1525 | 4110.6 | 1294 | 488.1–2101 | >10.000 |
Benzamides | |||||||
 SNX-5422 |  | 2136 | 161.9–2661 | 4322.6 | 2008 | 1155–2860 | 6648.4 |
 SNX-2112 | * | 665.0 | 577.2–752.9 | 4570.9 | 1702 | 697.4–2707 | >10.000 |
Purines | |||||||
 PUH71 |  | 3920 | 3410–4430 | >10.000 | 4420 | 3930–4910 | >10.000 |
 PUWS13 | * | 7000 | 6180–7820 | >10.000 | 3880 | 3400–4360 | 9060 |