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Table 5 Diagnostic performance of the RDT after correcting for the influence of other febrile illnesses and previous antimalarial intake per season

From: Accuracy of a Plasmodium falciparum specific histidine-rich protein 2 rapid diagnostic test in the context of the presence of non-malaria fevers, prior anti-malarial use and seasonal malaria transmission

 

True positive n (%)

True negative n (%)

False positive n (%)

False negative n (%)

Performance if bBSI, UTI, vGII and previous antimalarial intake are excluded

 Whole season (N = 583)

320 (54.9)

162 (27.8)

95 (16.3)

6 (1.0)

 Dry season (N = 280)

89 (31.8)

127 (45.4)

61 (21.8)

3 (1.1)

 Rainy season (N = 303)

231 (76.2)

35 (11.5)

34 (11.2)

3 (1.0)

Performance after exclusion of bBSI

 Whole season (N = 642)

328 (51.1)

190 (29.6)

118 (18.4)

6 (0.9)

 Dry season (N = 326)

91 (27.9)

153 (46.9)

79 (24.2)

3 (0.9)

 Rainy season (N = 316)

237 (75.0)

37 (11.7)

39 (12.3)

3 (0.9)

Performance after exclusion of UTI

 Whole season (N = 671)

329 (49.0)

201 (30.0)

135 (20.1)

6 (0.9)

 Dry season (N = 342)

97 (28.4)

159 (46.5)

83 (24.3)

3 (0.9)

 Rainy season (N = 329)

232 (70.5)

42 (12.8)

52 (15.8)

3 (0.9)

Performance after exclusion of vGII

 Whole season (N = 647)

326 (50.4)

188 (29.1)

127 (19.6)

6 (0.9)

 Dry season (N = 318)

94 (29.6)

147 (46.2)

74 (23.3)

3 (0.9)

 Rainy season (N = 329)

232 (70.5)

41 (12.5)

53 (16.1)

3 (0.9)

Performance if UTI and vGII are excluded

 Whole season (N = 615)

325 (52.8)

171 (27.8)

113 (18.4)

6 (1.0)

 Dry season (N = 295)

94 (31.9)

133 (45.1)

65 (22.0)

3 (1.0)

 Rainy season (N = 320)

231 (72.2)

38 (11.9)

48 (15.0)

3 (0.9)

Performance if antimalarial intake in the previous 2 weeks is excluded

 Whole season (N = 648)

333 (51.4)

182 (28.1)

127 (19.6)

6 (0.9)

 Dry season (N = 318)

97 (30.5)

143 (45.0)

75 (23.6)

3 (0.9)

 Rainy season (N = 330)

236 (71.5)

39 (11.8)

52 (15.8)

3 (0.9)

  1. Number of observed agreements: 499 (81.80% of the of the observation)
  2. Number of agreement expected by chance: 314.7 (51.59% of the observation)
  3. Kappa = 0.624
  4. SE of Kappa = 0.030
  5. 95% confidence interval: from 0.565 to 0.684
  6. The strength of agreement is considered to be “good”
  7. p < 0.00001