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Table 3 Association of CSF (a) KYNA and (b) kynurenine with clinical outcomes in 69 Ugandan children with cerebral malaria

From: Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Clinical outcome Value Odds ratio, rate ratio or risk difference (95% CI)a P
a
 Mortality OR 1.00 (0.99, 1.01) 0.60
 Neurologic deficits at discharge OR 1.00 (1.00, 1.001) 0.55
 Neurologic deficits, 6 mo follow-up OR 0.99 (0.987, 1.002) 0.17
 Number of convulsions in hospital IRR 1.00 (0.999, 1.000) 0.88
 Coma duration β 0.04 (0.01, 0.08) 0.04
b
 Mortality OR 1.49 (0.70, 3.16) 0.30
 Neurologic deficits at discharge OR 1.09 (0.79, 1.49) 0.61
 Neurologic deficits, 6 mo follow-up OR 0.99 (0.49, 1.99) 0.97
 Number of convulsions in hospital IRR 1.09 (0.97, 1.24) 0.15
 Coma duration β 9.1 (4.0, 14.3) 0.003
  1. OR odds ratio, IRR incidence rate ratio, 95% CI 95% confidence interval
  2. aLogistic regression (OR), negative binomial regression (IRR) or multiple linear regression (β coefficient), adjusted for age and lactate level