Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Table 3 Association of CSF (a) KYNA and (b) kynurenine with clinical outcomes in 69 Ugandan children with cerebral malaria

Clinical outcome	Value	Odds ratio, rate ratio or risk difference (95% CI)^a	P
a
Mortality	OR	1.00 (0.99, 1.01)	0.60
Neurologic deficits at discharge	OR	1.00 (1.00, 1.001)	0.55
Neurologic deficits, 6 mo follow-up	OR	0.99 (0.987, 1.002)	0.17
Number of convulsions in hospital	IRR	1.00 (0.999, 1.000)	0.88
Coma duration	β	0.04 (0.01, 0.08)	0.04
b
Mortality	OR	1.49 (0.70, 3.16)	0.30
Neurologic deficits at discharge	OR	1.09 (0.79, 1.49)	0.61
Neurologic deficits, 6 mo follow-up	OR	0.99 (0.49, 1.99)	0.97
Number of convulsions in hospital	IRR	1.09 (0.97, 1.24)	0.15
Coma duration	β	9.1 (4.0, 14.3)	0.003

OR odds ratio, IRR incidence rate ratio, 95% CI 95% confidence interval
^aLogistic regression (OR), negative binomial regression (IRR) or multiple linear regression (β coefficient), adjusted for age and lactate level

ISSN: 1475-2875