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Table 1 The protective efficacy against challenge by the bites of mosquitoes infected with PfCSP-Tc/Pb parasites

From: DAF-shielded baculovirus-vectored vaccine enhances protection against malaria sporozoite challenge in mice

Vaccine

Dose

No. of uninfected mice/total no. (%)

PBS

4

0/10 (0)

WT-AcNPV

4

0/10 (0)

BDES-PfCSP1-gp64

4

1/10 (10)

BDES-sPfCSP2-Spier

4

3/10 (30)a

BDES-sPfCSP2-Spider

4

6/10 (60)b

  1. Mice were screened for PfCSP-Tc/Pb blood-stage infections by microscopic examination of Giemsa-stained thin smears of tail blood after challenge infections. Protection is defined as the complete absence of blood-stage parasitemia on day 14 post-challenge
  2. a, bEach group of immunized mice were compared with the nonimmunized group (PBS) to test for statistically significant differences using Fisher’s exact probability test. a p < 0.05; b p < 0.01
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Malaria Journal

ISSN: 1475-2875

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