Fig. 3

Patients harbouring primary isolates that subsequently recrudesced have higher background recognition than patients that eliminated primary infections (P = 0.059). Shown here is the mean fluorescence intensity (MFI) of the heterologous recognition (of 14 isolates) by sera from 12 patients who eliminated their infections (and were later reinfected) (blue) compared to the 6 patients with recrudescences (red). The results are further divided into sera from day 0 (acute) and day 14 (convalescence) to show that the measured immune response is relatively stable, i.e. does not fluctuate from day to day, and is not due to submicroscopic infections still present in children with recrudescences in day 14 sera. Boxes show the interquartile range, whiskers the 5th–95th percentile and the median is shown as a horizontal bar. Single measurements outside the 5th–95th percentile are shown individually