Fig. 5

CDDO-EA treatment enhances BBB integrity. Evans blue dye was measured by spectrophotometer on day 6 post-infection. Treatments were administered on day 4 post-infection (CDDO-EA administered at 200 μmol/kg, ART at 5 mg/kg, 9 mice per group, data from two independent studies). a CDDO-EA monotherapy significantly reduced BBB leak compared to vehicle control alone (p = 0.009, Kruskal–Wallis test with Dunn’s correction) and co-administration of CDDO-EA with artesunate significantly reduced BBB extravasation compared to treatment with artesunate alone (p = 0.018, Kruskal–Wallis test with Dunn’s correction). b Representative images of brains of PbA-infected mice and their respective treatments. Images reflective of population medians are shown