Fig. 3
From: In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
Effects of combinations of cryptolepine with standard anti-malarial drugs on Plasmodium falciparum growth in vitro (3D7 strain). Isobolograms illustrating the effect of combinations of cryptolepine with amodiaquine (a), mefloquine (b), and chloroquine (c). The interaction between cryptolepine and amodiaquine, mefloquine, chloroquine or lumefantrine against ring stage parasites was determined using the SYBR Green I fluorescence-based drug sensitivity assay with the fixed ratio method. Each combination was set up in triplicate for 48 h. The FIC50 concentrations were used for plotting the isobologram