Skip to main content

Table 2 In vitro interaction of cryptolepine combinations against 3D7 P. falciparum strains

From: In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

Drug combination ΣFIC50 Mean ΣFIC50 Interaction
4:1 3:2 2:3 1:4
Cryptolepine + amodiaquine 0.640 ± 0.08 0.0234 ± 0.11 0.0631 ± 0.07 0.421 ± 0.12 0.287 ± 0.10 Synergism
Cryptolepine + mefloquine 3.015 ± 0.91 3.013 ± 1.01 5.106 ± 1.13 5.595 ± 0.91 4.182 ± 0.99 Antagonism
Cryptolepine + lumefantrine 2.1108 ± 0.17 1.6865 ± 0.01 0.1475 ± 0.02 0.1245 ± 0.04 1.017 ± 0.06 Additivity
Cryptolepine + chloroquine 1.95 ± 0.21 1.775 ± 0.36 1.66 ± 0.04 0.475 ± 0.05 1.465 ± 0.17 Additivity
  1. The ratios 4:1, 3:2, 2:3 and 1:4 refer to fixed dosage ratios for drug A (cryptolepine) to drug B (amodiaquine, mefloquine, lumefantrine, chloroquine). Values are the means from ≥ 3 experiments