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Table 2 In vitro interaction of cryptolepine combinations against 3D7 P. falciparum strains

From: In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

Drug combination

ΣFIC50

Mean ΣFIC50

Interaction

4:1

3:2

2:3

1:4

Cryptolepine + amodiaquine

0.640 ± 0.08

0.0234 ± 0.11

0.0631 ± 0.07

0.421 ± 0.12

0.287 ± 0.10

Synergism

Cryptolepine + mefloquine

3.015 ± 0.91

3.013 ± 1.01

5.106 ± 1.13

5.595 ± 0.91

4.182 ± 0.99

Antagonism

Cryptolepine + lumefantrine

2.1108 ± 0.17

1.6865 ± 0.01

0.1475 ± 0.02

0.1245 ± 0.04

1.017 ± 0.06

Additivity

Cryptolepine + chloroquine

1.95 ± 0.21

1.775 ± 0.36

1.66 ± 0.04

0.475 ± 0.05

1.465 ± 0.17

Additivity

  1. The ratios 4:1, 3:2, 2:3 and 1:4 refer to fixed dosage ratios for drug A (cryptolepine) to drug B (amodiaquine, mefloquine, lumefantrine, chloroquine). Values are the means from ≥ 3 experiments
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Malaria Journal

ISSN: 1475-2875

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