Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen-1 in Myanmar isolates

Table 1 Estimates of DNA sequence polymorphism and tests of neutrality at PfAMA-1 among Plasmodium falciparum Myanmar isolates

Fragment	Segregating sites (S)	Singleton variable sites	Parsimony informative sites	Total no. of mutations	K	H	Hd ± SD	π ± SD	dN − dS	Tajima’s D
5ʹ-Terminal	5	1	4	5	1.253	8	0.702 ± 0.052	0.00282 ± 0.00027	− 0.00227	0.37596 (P > 0.1)
Domain I	37	4	33	38	9.796	27	0.912 ± 0.024	0.02120 ± 0.00161	0.02516	0.64221 (P > 0.1)
Domain II	12	4	8	12	2.234	12	0.860 ± 0.023	0.00752 ± 0.00057	0.00794	− 0.39855 (P > 0.1)
Domain III	13	5	8	13	3.275	14	0.871 ± 0.024	0.01629 ± 0.00080	0.01484	0.48627 (P > 0.1)
3ʹ-Terminal	8	2	6	8	1.987	10	0.761 ± 0.027	0.00581 ± 0.00047	0.00658	0.39702 (P > 0.1)
Full	78	16	62	79	19.886	37	0.948 ± 0.019	0.01064 ± 0.00051	0.01076	0.57189 (P > 0.1)

K, average number of pairwise nucleotide differences; H, number of haplotypes; Hd, haplotype diversity; π, observed average pairwise nucleotide diversity; dN, rate of non-synonymous mutations; dS, rate of synonymous mutations

ISSN: 1475-2875