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Table 4 Association between nutrient supplementation and seroprevalence in 6 months old children

From: Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children

Outcome

Number of children seropositive/total number of children

Comparison between LNS and IFA group

Comparison between LNS and MMN group

Comparison between MMN and IFA group

IFAa

MMNb

LNSc

P valued

OR (95% CI)

P valuee

OR (95% CI)

P valuee

OR (95% CI)

P valuee

MSP-1f 19kD

43/145

(29.7%)

44/140

(31.4%)

41/147

(27.9%)

0.806

0.96 (0.74, 1.23)

0.739

0.84 (0.51, 1.40)

0.512

1.07 (0.64, 1.77)

0.804

Adjusted modelg

    

0.97 (0.73, 1.28)

0.808

0.86 (0.49, 1.49)

0.583

1.01 (0.57, 1.76)

0.981

MSP-2h

38/145

(26.2%)

40/140

(28.6%)

36/147

(24.5%)

0.734

0.96 (0.73, 1.24)

0.736

0.81 (0.48, 1.37)

0.434

1.07 (0.63, 1.80)

0.807

Adjusted modelg

    

0.98 (0.74, 1.31)

0.893

0.80 (0.45, 1.42)

0.447

1.09 (0.62, 1.94)

0.764

EBA-175i

15/145

(10.3%)

20/140

(14.3%)

13/147

(8.9%)

0.320

0.92 (0.62, 1.35)

0.663

0.58 (0.28, 1.22)

0.152

1.34 (0.65, 2.76)

0.426

Adjusted modelg

    

0.96 (0.63, 1.47)

0.857

0.54 (0.25, 1.18)

0.120

1.53 (0.70, 3.37)

0.289

Rh2A9j

9/145

(6.21%)

3/140

(2.14%)

2/147

(1.4%)

0.044

0.46 (0.21, 0.99)

0.047

0.63 (0.10, 3.83)

0.616

0.33 (0.09, 1.23)

0.098

Adjusted modelg

    

0.48 (0.21, 1.06)

0.070

0.79 (0.12, 5.42)

0.814

0.34 (0.09, 1.30)

0.114

Schizont extract

68/145

(46.9%)

67/140

(47.86%)

67/147

(45.6%)

0.927

0.97 (0.77, 1.23)

0.821

0.91 (0.57, 1.45)

0.699

1.07 (0.67, 1.71)

0.774

Adjusted modelg

    

0.91 (0.70, 1.18)

0.468

0.89 (0.53, 1.51)

0.677

0.97 (0.58, 1.63)

0.923

VSAk of E8B parasite line

31/145

(21.4%)

39/140

(27.9%)

35/147

(23.8%)

0.437

1.09 (0.83, 1.43)

0.552

0.80 (0.47, 1.36)

0.402

1.52 (0.88, 2.64)

0.134

Adjusted modelg

    

1.01 (0.74, 1.37)

0.957

0.70 (0.38, 1.26)

0.233

1.55 (0.86, 2.80)

0.146

VSA of R29 parasite line

14/145

(9.7%)

12/140

(8.6%)

11/147

(7.5%)

0.803

0.86 (0.57, 1.30)

0.470

0.83 (0.35, 1.94)

0.659

0.88 (0.39, 1.98)

0.756

Adjusted modelg

    

0.76 (0.48, 1.20)

0.234

0.69 (0.27, 1.74)

0.427

0.91 (0.38, 2.14)

0.822

VSA of 3D7 parasite line

27/145

(18.6%)

33/140

(23.6%)

34/147

(23.1%)

0.530

1.16 (0.87, 1.54)

0.313

0.97 (0.56, 1.69)

0.924

1.35 (0.76, 2.41)

0.301

Adjusted modelg

    

1.04 (0.75, 1.43)

0.829

0.89 (0.48, 1.65)

0.721

1.24 (0.66, 2.31)

0.501

  1. aIron and folic acid
  2. bMultiple micronutrients
  3. clipid based nutrient supplements
  4. d P value calculated using the Chi2 test
  5. e P value calculated using logistic regression reporting Odds Ratios (OR) and 95% Confidence intervals (CI)
  6. fMerozoite surface protein 1
  7. gP value calculated using multivariate logistic regression reporting odds ratios (OR) while adjusting for maternal BMI at enrolment, duration of gestation (from enrolment to delivery), number of pregnancies, sex of the child, maternal education, socioeconomic status, study site, maternal anaemic status at enrolment, maternal HIV status and bed net use by children
  8. hMerozoite surface protein 2
  9. iErythrocyte binding antigen 175
  10. jReticulocyte binding protein homologue 2A
  11. kVariant surface antigens
  12. Significant P values <0.05 are indicated in italics
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Malaria Journal

ISSN: 1475-2875

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