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Table 5 Association between nutrient supplementation and seroprevalence in 18 months old children

From: Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children

Outcome

Number of children seropositive/total number of children

Comparison between LNS and IFA group

Comparison between LNS and MMN group

Comparison between MMN and IFA group

IFAa

MMNb

LNSc

P valued

OR (95% CI)

P valuee

OR (95% CI)

P valuee

OR (95% CI)

P valuee

MSP-1 19kDf

82/145

(56.5%)

72/140

(51.4%)

82/147

(55.7%)

0.646

0.98 (0.78, 1.24)

0.895

1.19 (0.75, 1.90)

0.460

0.83 (0.52, 1.33)

0.444

Adjusted modelg

    

0.98 (0.77, 1.25)

0.865

1.10 (0.67, 1.82)

0.708

0.80 (0.48, 1.34)

0.398

MSP-2h

42/145

(28.9%)

39/140

(27.8%)

36/147

(24.4%)

0.669

0.88 (0.66, 1.16)

0.359

0.79 (0.45, 1.40)

0.428

0.95 (0.54, 1.66)

0.851

Adjusted modelg

    

0.82 (0.60, 1.13)

0.226

0.63 (0.34, 1.18)

0.149

0.96 (0.53, 1.76)

0.906

EBA-175i

19/145

(13.1%)

14/140

(10.0%)

18/147

(12.2%)

0.705

0.99 (0.67, 1.43)

0.967

1.59 (0.69, 3.63)

0.273

0.61 (0.27, 1.40)

0.242

Adjusted modelg

    

0.91 (0.60, 1.37)

0.642

1.19 (0.48, 2.95)

0.710

0.65 (0.27, 1.58)

0.342

Rh2A9j

42/145

(28.9%)

40/140

(28.5%)

40/147

(27.2%)

0.941

0.96 (0.74, 1.24)

0.739

0.93 (0.56, 1.57)

0.797

0.96 (0.57, 1.61)

0.880

Adjusted modelg

    

0.96 (0.73, 1.26)

0.763

0.84 (0.48, 1.47)

0.540

0.98 (0.56, 1.71)

0.931

Schizont extract

73/145

(50.3%)

78/140

(55.7%)

82/147

(55.7%)

0.568

1.12 (0.89, 1.40)

0.352

1.003 (0.63, 1.60)

0.991

1.24 (0.78, 1.99)

0.365

Adjusted modelg

    

1.18 (0.90, 1.54)

0.223

0.87 (0.52, 1.46)

0.600

1.40 (0.83, 2.35)

0.208

VSAk of E8B parasite line

14/145

(9.6%)

11/140

(7.9%)

9/147

(6.1%)

0.534

0.78 (0.51, 1.21)

0.266

0.76 (0.30, 1.89)

0.554

0.78 (0.33, 1.83)

0.562

Adjusted modelg

    

0.80 (0.50, 1.29)

0.360

0.72 (0.27, 1.89)

0.504

0.75 (0.29, 1.93)

0.557

VSA of R29 parasite line

7/145

(4.8%)

5/140

(3.5%)

4/147

(2.7%)

0.632

0.74 (0.40, 1.39)

0.351

0.76

(0.20, 2.87)

0.680

0.72 (0.22, 2.32)

0.582

Adjusted modelg

    

0.79 (0.39, 1.60)

0.506

0.95 (0.22, 4.07)

0.946

0.85 (0.23, 3.14)

0.808

VSA of 3D7 parasite line

15/145

(10.3%)

11/140

(7.8%)

10/147

(6.8%)

0.532

0.80 (0.52, 1.21)

0.283

0.86 (0.35, 2.08)

0.732

0.85 (0.37, 1.97)

0.710

Adjusted modelg

    

0.74 (0.46, 1.22)

0.241

0.55 (0.20, 1.52)

0.250

1.11(0.43, 2.83)

0.830

  1. aIron and folic acid
  2. bMultiple micronutrients
  3. clipid based nutrient supplements
  4. d P-value calculated using the Chi2 test
  5. e P-value calculated using logistic regression reporting Odds Ratios (OR) and 95% Confidence intervals (CI)
  6. fMerozoite surface protein 1
  7. gP-value calculated using multivariate logistic regression reporting odds ratios (OR) while adjusting for maternal BMI at enrolment, duration of gestation (from enrolment to delivery), number of pregnancies, sex of the child, maternal education, socioeconomic status, study site, maternal anaemic status at enrolment, maternal HIV status and bed net use by children
  8. hMerozoite surface protein 2
  9. iErythrocyte binding antigen 175
  10. jReticulocyte binding protein homologue 2A
  11. kVariant surface antigens
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Malaria Journal

ISSN: 1475-2875

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