Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT

Table 2 Prevalence of msp-1 K1, MAD20, and RO33 allelic variants collected from Plasmodium falciparum isolates along Grande Comore Island in 2006–2007 and 2013–2016 periods

K1 allele	Number of isolates (%)^a		MAD20 allele	Number of isolates (%)^a		RO33 allele	Number of isolates (%)^a
	2006–2007	2013–2016		2006–2007	2013–2016		2006–2007	2013–2016
	(n = 40)	(n = 44)		(n = 20)	(n = 12)		(n = 42)	(n = 54)
K1-1	2 (5.0)	0 (0)*	MAD20-1	5 (25.0)	5 (41.6)**	RO33-1	7 (21.2)	32 (59.3)**
K1-2	0 (0)	2 (4.5)*	MAD20-2	1 (5.0)	2 (16.6)**	RO33-2	2 (6.1)	3 (5.6)
K1-3	1 (2.5)	0 (0)	MAD20-3	2 (10.0)	5 (41.6)**	RO33-3	8 (24.2)	1 (1.9)**
K1-4	3 (7.5)	0 (0)**	MAD20-4	3 (15.0)	0 (0)**	RO33-4	2 (6.1)	1 (1.9)
K1-5	0 (0)	5 (11.4)**	MAD20-5	2 (10.0)	0 (0)**	RO33-5	4 (12.1)	1 (1.9)**
K1-6	3 (7.5)	2 (4.5)	MAD20-6	2 (10.0)	0 (0)**	RO33-6	2 (6.1)	0 (0)**
K1-7	5 (12.5)	5 (11.5)	MAD20-7	1 (5.0)	0 (0)*	RO33-7	0 (0)	3 (5.6)*
K1-8	0 (0)	3 (6.8)**	MAD20-8	1 (5.0)	0 (0)*	RO33-8	3 (9.1)	0 (0)**
K1-9	2 (5.0)	2 (4.5)	MAD20-9	3 (15.0)	0 (0)**	RO33-9	0 (0)	2 (3.7)
K1-10	3 (7.5)	0 (0)**				RO33-10	3 (9.1)	0 (0)**
K1-11	2 (5.0)	8 (18.2)**				RO33-11	0 (0)	8 (14.8)**
K1-12	2 (5.0)	2 (4.5)				RO33-12	2 (6.1)	3 (5.6)
K1-13	3 (7.5)	9 (20.5)**
K1-14	0 (0)	2 (4.5)*
K1-15	2 (5.0)	0 (0)*
K1-16	1 (2.5)	0 (0)
K1-17	3 (7.5)	0 (0)**
K1-18	8 (20.0)	4 (9.1)*

^aStatistically significant differences for comparison with isolates circulating in 2006–2007 from Grande Comore island (* P < 0.05; ** P < 0.01) using Mann–Whitney U test

ISSN: 1475-2875