Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT

Table 3 Prevalence of msp-2 FC27 and 3D7 allelic variants collected from Plasmodium falciparum isolates along Grande Comore Island in 2006–2007 and 2013–2016 periods

FC27 allele	Number of isolates (%)^a		3D7 allele	Number of isolates (%)^a
FC27 allele	2006–2007 (n = 62)	2013–2016 (n = 80)	3D7 allele	2006–2007 (n = 56)	2013–2016 (n = 33)
FC27-1	4 (6.4)	8 (10.0)	3D7-1	4 (7.1)	2 (6.1)
FC27-2	1 (1.6)	3 (3.8)	3D7-2	19 (34.0)	2 (6.1)**
FC27-3	2 (3.2)	2 (2.5)	3D7-3	3 (5.4)	3 (9.1)
FC27-4	0 (0)	3 (3.7)	3D7-4	4 (7.2)	0 (0)**
FC27-5	8 (12.9)	0 (0)**	3D7-5	3 (5.4)	0 (0)*
FC27-6	3 (4.8)	0 (0)**	3D7-6	1 (1.8)	0 (0)
FC27-7	6 (9.7)	0 (0)**	3D7-7	0 (0)	3 (9.1)**
FC27-8	0 (0)	2 (2.5)	3D7-8	3 (5.4)	2 (6.1)
FC27-9	2 (3.2)	3 (3.8)	3D7-9	6 (10.7)	16 (48.5)**
FC27-10	8 (12.9)	2 (2.5)**	3D7-10	2 (3.6)	0 (0)
FC27-11	4 (6.5)	0 (0)**	3D7-11	3 (5.4)	2 (6.1)
FC27-12	3 (4.8)	2 (2.5)	3D7-12	0 (0)	3 (9.1)**
FC27-13	3 (4.8)	3 (3.8)	3D7-13	4 (7.1)	0 (0)**
FC27-14	7 (11.3)	47 (58.8)**	3D7-14	1 (1.8)	0 (0)
FC27-15	0 (0)	2 (2.5)	3D7-15	3 (5.4)	0 (0)*
FC27-16	5 (8.1)	0 (0)**
FC27-17	0 (0)	1 (1.3)
FC27-18	0 (0)	2 (2.5)
FC27-19	3 (4.8)	0 (0)**
FC27-20	1 (1.6)	0 (0)
FC27-21	2 (3.2)	0 (0)

^a Statistically significant differences for comparison with isolates circulating in 2006–2007 from Grande Comore island (* P < 0.05; ** P < 0.01) using Mann–Whitney U test

ISSN: 1475-2875