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Table 2 Cytokine levels in the semi-immune mice of Balb/c, F1 and CBA

From: Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA

Cytokine (pg/mL)

Mouse strains (number)

p value*

F1 (n = 5)

Balb/c (n = 5)

CBA (n = 5)

Uninfected control (3)

IL-1α (SD)

1.0 (0.2)

1.4 (0.6)

1.2 (0.1)

0.9 (0.1)

0.244

IL-4 (SD)

0.8 (0.1)

0.8 (0.1)

0.6 (0.1)

0.5 (0.1)

0.017

IL-10 (SD)

1.3 (0.1)

1.4 (0.4)

1.6 (0.2)

1.3 (0.2)

0.125

IL-12 (SD)

3.2 (0.2)

3.4 (0.2)

2.9 (0.5)

2.6 (0.2)

0.018

IL-17 (SD)

3.1 (0.4)

3.3 (0.7)

0.8a (0.04)

0.7a (0.05)

< 0.0001

IFN-γ (SD)

0.8 (0.1)

1.3b (0.3)

0.8 (0.1)

0.6 (0.04)

0.002

TNF-α (SD)

1.5c (0.1)

1.6 (0.2)

1.8 (0.2)

1.6 (0.04)

0.066

TNF-α: IL-10 (SD)

0.2 (0.2)

0.2 (0.4)

0.1 (0.1)

0.3 (0.2)

0.874

  1. Blood was harvested when mice were sacrificed at minimum Hb. Values are results of one experiment. Similar results were obtained in a repeat experiment
  2. * p values done by ANOVA was performed on the log10 transformed data. Analysis was done by ANOVA with Tukey’s post test. Values represented are mean of the log10 transformed data with standard deviation (SD)
  3. aSignificantly lower than F1 and Balb/c
  4. bSignificantly higher than the other strain and the negative control
  5. cSignificantly lower than CBA
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Malaria Journal

ISSN: 1475-2875

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