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Table 4 Regression analysis of mean antibody levels to 11 VAR2CSA domains during pregnancy and at delivery on birth weight and gestational age

From: Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes

Sampling time Outcome Graviditya OR (95% CI) p value
Enrollment LBW Primigravid 1.84 (0.43–9.20) 0.4
Multigravid 0.84 (0.30–2.53) 0.7
SGA Primigravid 1.97 (0.62–7.093) 0.3
Multigravid 0.58 (0.25–1.44) 0.2
Gestational week 30–32 LBW Primigravid 7.06 (0.61–131.45) 0.1
Multigravid 0.72 (0.23–2.45) 0.6
SGA Primigravid 1.36 (0.24–8.50) 0.7
Multigravid 0.69 (0.27–1.99) 0.5
Delivery LBW Primigravid 3.34 (0.70–19.47) 0.2
Multigravid 0.66 (0.25–1.87) 0.4
SGA Primigravid 2.34 (0.59–11.11) 0.3
Multigravid 0.76 (0.34–1.88) 0.5
Sampling time Outcome Gravidity β p value
Enrollment BW Primigravid − 0.14 0.02
Multigravid 0.02 0.7
GA Primigravid − 0.77 0.07
Multigravid − 0.05 0.8
Gestational week 30–32 BW Primigravid − 0.16 0.07
Multigravid − 0.01 0.8
GA Primigravid − 0.84 0.1
Multigravid 0.24 0.2
Delivery BW Primigravid − 0.13 0.03
Multigravid − 0.02 0.7
GA Primigravid − 0.53 0.2
Multigravid − 0.02 0.9
  1. Models were adjusted for malaria infection, number of IPTp doses and ITN. The analyses of LBW and BW were also adjusted for gestational age
  2. LBW low birthweight, SGA small for gestational age, BW birthweight, GA gestational age
  3. aPrimigravid, 1st pregnancy; Multigravid, ≥ 1 previous pregnancies