Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region

Table 3 Genetic diversity estimators and neutral tests

n	Gene	Sites	Ss	H	Hd	θ	π	d_N–d_S	Fay and Wu
n	Gene	Sites	Ss	H	Hd	θ	π	d_N–d_S	H
41	dhfr	558	10	10	0.84	0.0040	0.0037	− 0.006*	− 3.64^†
48	dhps	648	3	4	0.56	0.0010	0.0011	0.002	0.32
50	mdr1	522	5	5	0.55	0.0021	0.0013	0.001	− 1.50^†
33	crt-o	375	0	0	0.00	0.0000	0.0000	–	–

n total sequences used for analysis, Sites total sites used to rule out gap sites, Ss amount of segregating sites, H amount of haplotypes, Hd haplotype diversity, θ nucleotide polymorphism per site, π nucleotide diversity per site, d_N–d_S ratio of non-synonymous to synonymous nucleotide polymorphism
* p = 0.038
^†p < 0.01

ISSN: 1475-2875