Fig. 4

Synergistic compound combinations identified against P. falciparum. Representation of dose–response matrix and HSA synergy model for tacrolimus-hydroxyzine (a, b) and raloxifene-thioridazine (c, d) in the three parasite lines (3D7, DD2, HB3). The effect of increasing drug concentration from right to left and bottom to top was assessed in a 10 × 10 block size matrix (a, c). HSA synergy model represents in which concentrations maximum synergy occurs (b, d)