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Table 4 Precision and recall calculated for synergistic compounds

From: A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Strain Mild-to-strong synergy (gamma ≤ 0.995) Moderate-to-strong synergy (gamma ≤ 0.975) Strong synergy (gamma ≤ 0.95)
3D7 DD2 HB3 AVG 3D7 DD2 HB3 AVG 3D7 DD2 HB3 AVG
True positives 18 18 19 18.3 7 13 12 10.7 2 5 1 2.7
False negatives 11 7 12 10.0 3 4 3 3.3 1 2 1 1.3
False positives 5 4 2 3.7 16 9 9 11.3 21 17 20 19.3
Precision (%) 78.3 81.8 90.5 83.3 30.4 59.1 57.1 48.5 8.7 22.7 4.8 12.1
Recall (%) 62.1 72.0 61.3 64.7 70.0 76.5 80.0 76.2 66.7 71.4 50.0 66.7
F measure (%) 69.2 76.6 73.1 72.8 42.4 66.7 66.7 59.3 15.4 34.5 8.7 20.5
Training set synergies (%) 42.8 41.2 40.0 41.3 25.7 25.3 23.0 24.7 15.8 15.6 13.4 14.9
  1. Precision and recall was calculated for each of the three P. falciparum strains with respect to three different cut-offs for gamma to distinguish the performance of the algorithm for mild-to-strong, moderate-to-strong and strong synergy. As you can see in all of the predictions recall has been kept high between 50 and 80% depending the expected synergy level and the strain. The highest precision is for Mild-to-strong synergies ranging from 61.3 to 72%. However, as the synergy level expectation is increased to Moderate-to-strong or only Strong synergies the Precision drops to 30–59% and 4.8–22.7%