A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Malaria Journal

Table 4 Precision and recall calculated for synergistic compounds

Strain	Mild-to-strong synergy (gamma ≤ 0.995)				Moderate-to-strong synergy (gamma ≤ 0.975)				Strong synergy (gamma ≤ 0.95)
Strain	3D7	DD2	HB3	AVG	3D7	DD2	HB3	AVG	3D7	DD2	HB3	AVG
True positives	18	18	19	18.3	7	13	12	10.7	2	5	1	2.7
False negatives	11	7	12	10.0	3	4	3	3.3	1	2	1	1.3
False positives	5	4	2	3.7	16	9	9	11.3	21	17	20	19.3
Precision (%)	78.3	81.8	90.5	83.3	30.4	59.1	57.1	48.5	8.7	22.7	4.8	12.1
Recall (%)	62.1	72.0	61.3	64.7	70.0	76.5	80.0	76.2	66.7	71.4	50.0	66.7
F measure (%)	69.2	76.6	73.1	72.8	42.4	66.7	66.7	59.3	15.4	34.5	8.7	20.5
Training set synergies (%)	42.8	41.2	40.0	41.3	25.7	25.3	23.0	24.7	15.8	15.6	13.4	14.9

Precision and recall was calculated for each of the three P. falciparum strains with respect to three different cut-offs for gamma to distinguish the performance of the algorithm for mild-to-strong, moderate-to-strong and strong synergy. As you can see in all of the predictions recall has been kept high between 50 and 80% depending the expected synergy level and the strain. The highest precision is for Mild-to-strong synergies ranging from 61.3 to 72%. However, as the synergy level expectation is increased to Moderate-to-strong or only Strong synergies the Precision drops to 30–59% and 4.8–22.7%

ISSN: 1475-2875