Table 1 Physicochemical characteristics of SLN and Hep-SLN (empty and drug-loaded)
DRUG | Size(nm) (Mean ± std dev.) | PDI (Mean ± std dev.) | Zeta (mV) (Mean ± std dev.) | Drug-loading (%) | EE (%) |
|---|---|---|---|---|---|
SLN | 482.2 ± 12.0 | 0.245 ± 0.023 | 24.0 ± 0.321 | – | – |
SLN-CQ | 444.5 ± 6.9 | 0.175 ± 0.021 | 9.41 ± 0.376 | 25 | 90 |
SLN-HEP | 379.2 ± 1.2 | 0.346 ± 0.028 | − 5.73 ± 0.267 | – | – |
SLN-HEP-CQ | 374.6 ± 7.6 | 0.272 ± 0.053 | − 4.06 ± 0.091 | 21 | 78 |