Skip to main content

Table 2 Antibody responses in women with and without placental infection

From: IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy

 

No inflammation (n = 197)

Inflammation (n = 10)

p

Multivariatea

GM

SD

GM

SD

Ratio

(95% CI)

p

Maternal IgGs

 MSP1

65.41

58.42

62.84

62.76

0.891

0.88

(0.49; 1.57)

0.665

 EBA175

44.17

33.09

42.24

26.13

0.853

0.89

(0.55; 1.44)

0.636

 AMA1

61.45

37.81

63.18

30.41

0.889

0.96

(0.64; 1.42)

0.824

 DBLa

77.56

30.62

69.28

21.26

0.375

0.83

(0.65; 1.07)

0.145

 Lysate

31.68

40.32

43.07

26.07

0.450

1.16

(0.52; 2.58)

0.719

 CS2

2.16

1.62

1.83

1.07

0.492

0.93

(0.79; 1.10)

0.396

 Women1

149.75

227.78

93.63

96.67

0.336

0.68

(0.28; 1.62)

0.386

 Women2

412.18

580.46

216.39

228.31

0.156

0.56

(0.24; 1.28)

0.171

 SEV

2.72

0.88

2.39

0.90

0.228

0.97

(0.93; 1.02)

0.245

 Child1

249.09

227.92

178.53

187.45

0.266

0.67

(0.37; 1.22)

0.193

 Child2

641.87

547.08

544.20

448.88

0.550

0.82

(0.47; 1.44)

0.496

 Child3

653.83

474.55

443.80

366.64

0.103

0.67

(0.42; 1.08)

0.105

 Child4

183.91

180.67

128.46

158.73

0.267

0.64

(0.34; 1.23)

0.186

Maternal IgMs

 MSP1

75.22

45.36

40.66

32.52

0.002

0.53

(0.36; 0.80)

0.002

 EBA175

39.44

27.08

18.37

15.24

0.001

0.46

(0.29; 0.72)

0.001

 AMA1

51.87

31.25

29.61

28.32

0.006

0.58

(0.38; 0.86)

0.008

 DBLa

76.29

38.64

39.61

35.11

< 0.001

0.53

(0.38; 0.74)

< 0.001

 Lysate

16.06

29.12

15.58

24.48

0.958

0.91

(0.28; 2.93)

0.87

Cord IgGs

 MSP1

54.18

51.79

41.54

45.09

0.396

0.69

(0.37; 1.28)

0.237

 EBA175

40.16

31.79

40.62

33.98

0.965

0.92

(0.55; 1.55)

0.753

 AMA1

60.89

40.77

67.26

27.17

0.643

1

(0.66; 1.53)

0.989

 DBLa

60.72

27.78

65.68

28.77

0.597

0.98

(0.73; 1.31)

0.891

 Lysate

28.55

34.11

25.50

17.50

0.768

0.77

(0.36; 1.64)

0.495

 CS2

2.30

1.73

2.12

1.39

0.726

0.98

(0.83; 1.16)

0.804

 SEV

2.61

0.81

2.35

0.74

0.304

0.98

(0.94; 1.02)

0.288

Cord IgMs

 MSP1

10.76

5.54

11.92

8.08

0.546

1.1

(0.79; 1.54)

0.575

 EBA175

4.83

3.04

6.36

6.91

0.197

1.3

(0.85; 1.99)

0.231

 AMA1

6.88

3.79

8.43

7.34

0.272

1.23

(0.85; 1.77)

0.275

 DBLa

10.67

5.45

12.57

9.02

0.335

1.18

(0.84; 1.64)

0.344

 Lysate

6.89

5.64

6.85

5.77

0.984

1.06

(0.62; 1.81)

0.827

  1. GM geometric mean, SD standard deviation
  2. aAdjusted for parity, age, neighbourhood, ITN, season and IRS