Table 1 In vitro drug sensitivity of P. falciparum isolated from along the Thai–Cambodia border collected before 2009 and from 2009 to 2016
Drug | Mean IC50 (n) | Min–Max IC50 | Mean IC50 Before 2009 (n) | Mean IC50 2009–2016 (n) | p value |
|---|---|---|---|---|---|
CQ | 105.0 ± 53.0 (101) | 13.9–334.6 | 90.2 ± 37.5 (50) | 120.5 ± 61.4 (51) | 0.004 |
QN | 218.4 ± 131.5 (101) | 34.5–737.9 | 181.4 ± 107.9 (50) | 256.5 ± 142.0 (51) | 0.004 |
MQ | 28.2 ± 25.8 (101) | 1.7–130.9 | 20.4 ± 23.1 (50) | 35.5 ± 26.1 (51) | 0.003 |
PPQ | 22.0 ± 11.9 (90) | 6.4–74.8 | 17.1 ± 6.9 (43) | 26.1 ± 13.6 (47) | < 0.001 |
ARS | 3.0 ± 1.8 (101) | 0.5–9.7 | 2.6 ± 1.3 (50) | 3.5 ± 2.1 (51) | 0.008 |
DHA | 2.5 ± 1.2 (95) | 0.8–6.2 | 2.6 ± 1.2 (44) | 2.3 ± 1.1 (51) | 0.218 |
ATQ | 1.5 ± 1.3 (50) | 0.2–6.7 | – | 1.5 ± 1.3 (50) | – |
PG | 53.9 ± 20.3 (50) | 21.5–115.2 | – | 53.9 ± 20.3 (50) | – |