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Table 1 In vitro drug sensitivity of P. falciparum isolated from along the Thai–Cambodia border collected before 2009 and from 2009 to 2016

From: Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project

Drug Mean IC50
(n)
Min–Max IC50 Mean IC50
Before 2009
(n)
Mean IC50
2009–2016
(n)
p value
CQ 105.0 ± 53.0
(101)
13.9–334.6 90.2 ± 37.5
(50)
120.5 ± 61.4
(51)
0.004
QN 218.4 ± 131.5
(101)
34.5–737.9 181.4 ± 107.9
(50)
256.5 ± 142.0
(51)
0.004
MQ 28.2 ± 25.8
(101)
1.7–130.9 20.4 ± 23.1
(50)
35.5 ± 26.1
(51)
0.003
PPQ 22.0 ± 11.9
(90)
6.4–74.8 17.1 ± 6.9
(43)
26.1 ± 13.6
(47)
< 0.001
ARS 3.0 ± 1.8
(101)
0.5–9.7 2.6 ± 1.3
(50)
3.5 ± 2.1
(51)
0.008
DHA 2.5 ± 1.2
(95)
0.8–6.2 2.6 ± 1.2
(44)
2.3 ± 1.1
(51)
0.218
ATQ 1.5 ± 1.3
(50)
0.2–6.7 1.5 ± 1.3
(50)
PG 53.9 ± 20.3
(50)
21.5–115.2 53.9 ± 20.3
(50)
  1. Significant differences of drug IC50s between parasites collected before 2009 and from 2009 to 2016 determined using Independent t test