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Table 3 Performance of LM, RDT and LAMP for diagnosing malaria in peripheral blood samples

From: Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia

Test

 

Value (95% CI)

nPCRa

Sensitivity

Specificity

PPV

NPV

Kappa

(+)

(−)

Total

LM

 (+)

31

0

31

79.5% (64.5–89.2)

100.0% (99.2–100.0)

100.0% (89.0–100.0)

98.4% (96.9–99.2)

0.9 (0.8–1.0)

 (−)

8

492

500

RDT

 (+)

30

0

30

76.9% (61.7–87.4)

100.0% (99.2–100.0)

100.0% (88.6–100.0)

98.2% (96.6–99.1)

0.9 (0.8–1.0)

 (−)

9

492

501

LAMP

 (+)

39

0

39

100.0% (92.4–100.0)

100.0% (99.2–100.0)

100.0% (92.0–100.0)

100.0% (99.2–100.0)

1.00 (1.0–1.0)

 (−)

0

492

492

  1. LM: light microscopy; RDT: rapid diagnostic test; LAMP: loop-mediated isothermal amplification; nPCR: nested polymerase chain reaction; (+): positive; (−): negative; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval
  2. anPCR was used as the reference test