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Table 2 In vitro anti-plasmodial and cytotoxic activity of Iso-mukaadial acetate (NN-01)

From: Isolation, characterization, and biological evaluation of a potent anti-malarial drimane sesquiterpene from Warburgia salutaris stem bark

Sample code aIC50 (µg/ml) CC50 (µg/ml) Selectivity index
HEK293 HEPG2 HEK293 HEPG2
W. Salutaris 0.01 ± 0.30 21.30 ± 01 55.21 ± 11 2130 5521
NN-01 0.44 ± 0.10 36.7 ± 08 119.2 ± 88 83 270
CQ 4.9 ± 0.07 ng/ml 232.45 ± 21 350.04 ± 90 47,438 71,436
Art < 2 ng/ml N/D N/D N/D N/D
  1. ND Not determined
  2. aIC50: Inhibitory concentration