Isolation, characterization, and biological evaluation of a potent anti-malarial drimane sesquiterpene from Warburgia salutaris stem bark

Table 2 In vitro anti-plasmodial and cytotoxic activity of Iso-mukaadial acetate (NN-01)

Sample code	^aIC₅₀ (µg/ml)	CC₅₀ (µg/ml)		Selectivity index
Sample code	^aIC₅₀ (µg/ml)	HEK293	HEPG2	HEK293	HEPG2
W. Salutaris	0.01 ± 0.30	21.30 ± 01	55.21 ± 11	2130	5521
NN-01	0.44 ± 0.10	36.7 ± 08	119.2 ± 88	83	270
CQ	4.9 ± 0.07 ng/ml	232.45 ± 21	350.04 ± 90	47,438	71,436
Art	< 2 ng/ml	N/D	N/D	N/D	N/D

ISSN: 1475-2875