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Table 3 Analysis of negative samples by SnM-PCR

From: Comparison of three diagnostic methods (microscopy, RDT, and PCR) for the detection of malaria parasites in representative samples from Equatorial Guinea

 

RDT (n = 963)

Microscopy (n = 1069)

P-value

N

%

95% CI

N

%

95% CI

P. falciparum

122

95.3

90.2–97.8

326

97.3

95–98.6

0.276

P. malariae

1

0.8

0.1–4.3

1

0.3

0.1–1.7

0.47

P. ovale

3

2.3

0.8–6.7

2

0.6

0.2–2.2

0.10

P. vivax

1

0.8

0.1–4.3

1

0.3

0.1–1.7

0.47

Mix

1

0.8

0.1–4.3

5

1.5

0.6–3.4

0.47

Total positives

128

13.3

11.3–15.6

335

31.3

28.6–34.2

< 0.001

  1. Negative samples obtained by RDT (963) and microscopy (1069) that were analyzed by SnM-PCR. The species and mixed infections detected are showed in the table. Samples that finally appear as positive were considered false negatives, 128 in RDT and 335 in microscopy. The frequency of false negatives in relation to the total samples analyzed (1724) was 7.4% in RDT and 19.4% in microscopy
  2. Italic values indicate significance of P-value (≤ 005)
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Malaria Journal

ISSN: 1475-2875

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