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Table 7 Comparison of performance of drug seller, laboratory scientist and RDT-PCR diagnostic strategies against PCR detection of P. falciparum DNA extracted from FTA card (FTA-PCR)

From: Can malaria rapid diagnostic tests by drug sellers under field conditions classify children 5 years old or less with or without Plasmodium falciparum malaria? Comparison with nested PCR analysis

Diagnostic strategy Sensitivity %, (95% CI) Specificity %, (95% CI) Predictive value Likelihood ratio Methods agreement %, (95% CI) κ, (95% CI)
Positive test %, (95% CI) Negative test %, (95% CI) Positive test % Negative test %
Drug seller interpretation of RDT strip (drug seller) 81.7, (69.6, 90.5) 90.6, (84.5, 94.9) 79.0, (66.8, 88.3) 92.0, (86.1, 95.9) 8.7 0.2 87.9, (82.6, 92.1) 0.72, (0.61, 0.82)
Laboratory scientist re-reading of RDT strip (laboratory scientist) 86.9, (75.8, 94.2) 95.7, (90.8, 98.4) 89.8, (79.2, 96.2) 94.3, (89.1, 97.5) 20.0 0.1 92.9, (88.5, 96.1) 0.83, (0.75, 0.92)
PCR analysis of P. falciparum DNA extracted from RDT nitrocellulose strip (RDT-PCR) 76.6, (64.3, 86.2) 95.9, (91.4, 98.5) 89.1, (77.8, 95.9) 90.4, (84.7, 94.6) 18.9 0.2 90.1, (85.3, 93.8) 0.76, (0.66, 0.85)