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Table 1 Genetic polymorphism and tests of neutrality in C-terminal region of global PfCSP

From: Genetic polymorphism and natural selection of circumsporozoite surface protein in Plasmodium falciparum field isolates from Myanmar

Country n K S Total No. of mutations H Hd ± SD π ± SD dN–dS Tajima’s DP-value Fu and Li’s DP-value Fu and Li’s FP-value
Asia
Myanmar 51 0.92 3 3 3 0.329 ± 0.072 0.004 ± 0.003 0.005 ± 0.003 0.764a 0.889a 0.992a
Vietnam 23 4.39 14 16 23 1.000 ± 0.013 0.019 ± 0.001 0.024 ± 0.008 0.050a 0.862a 0.722a
Thailand 223 1.74 12 13 8 0.485 ± 0.039 0.009 ± 0.001 0.011 ± 0.004 − 0.483a 1.475d 0.886a
Philippines 42 5.79 18 19 9 0.821 ± 0.041 0.028 ± 0.001 0.033 ± 0.009 1.019a 1.649b 1.701c
Iran 21 0.93 2 2 2 0.467 ± 0.075 0.004 ± 0.001 0.006 ± 0.004 1.564a 0.858a 1.205a
India 15 3.71 18 19 13 0.981 ± 0.031 0.019 ± 0.004 0.023 ± 0.007 − 1.486a − 1.173a − 1.448a
Total 375 2.73 25 29 38 0.653 ± 0.027 0.013 ± 0.001 0.016 ± 0.005 − 1.032a − 0.235a − 0.698a
Oceania
PNG 94 1.17 5 5 4 0.532 ± 0.034 0.006 ± 0.001 0.007 ± 0.004 0.419a − 0.012a 0.151a
Vanuatu 116 0.55 2 2 2 0.276 ± 0.046 0.003 ± 0.001 0.003 ± 0.002 0.706a 0.674a 0.801a
Solomon Islands 51 0.83 4 4 3 0.397 ± 0.066 0.004 ± 0.0007 0.005 ± 0.003 − 0.1426a − 1.209a − 1.029a
Total 261 1.09 5 5 4 0.522 ± 0.012 0.005 ± 0.0002 0.007 ± 0.004 0.626a − 0.214a 0.087a
Africa
Kenya 18 5.83 17 20 12 0.922 ± 0.051 0.028 ± 0.003 0.035 ± 0.011 0.010a 0.295a 0.247a
Cameroon 9 4.56 12 15 7 0.944 ± 0.07 0.022 ± 0.005 0.028 ± 0.009 − 0.842a − 0.689a − 0.813a
Gambia 44 5.83 18 21 20 0.944 ± 0.019 0.028 ± 0.002 0.036 ± 0.009 0.677a 1.006a 1.068a
Ghana 33 5.02 18 22 19 0.932 ± 0.028 0.024 ± 0.003 0.031 ± 0.009 − 0.257a 0.474a 0.278a
Tanzania 60 6.45 22 26 30 0.969 ± 0.008 0.031 ± 0.001 0.039 ± 0.011 0.499a 0.852a 0.863a
Senegal 11 4.54 10 12 9 0.964 ± 0.051 0.019 ± 0.002 0.024 ± 0.007 0.475a 1.149a 1.106a
Total 175 21.76 150 169 58 0.968 ± 0.004 0.105 ± 0.021 0.169 ± 0.055 − 0.831a 2.648b 1.205a
South America
Venezuela 10 6.44 14 16 7 0.911 ± 0.077 0.031 ± 0.003 0.034 ± 0.014 0.645a 0.799a 0.857a
Brazil 42 2.33 8 8 3 0.459 ± 0.08 0.011 ± 0.002 0.014 ± 0.005 0.721a 1.309d 1.317a
Total 52 3.74 16 18 9 0.630 ± 0.065 0.018 ± 0.002 0.022 ± 0.007 − 0.188a 0.431a 0.257a
  1. PNG Papua New Guinea, n number of sequences analysed, S number of Segregating sites, K average number of nucleotide differences, H number of Haplotypes, Hd haplotype diversity, π observed average pairwise nucleotide diversity, dN rate of non-synonymous mutations, dS rate of synonymous mutations, SD standard deviation
  2. aP > 0.1; b P < 0.02; c P < 0.05; d 0.05 < P < 0.1