Fig. 4

Deduced amino acid residues of four clones isolated after competitive biopanning. The PfHRP2-specific clone was represented by H8; The PfLDH-specific clones were P16 and P2–3; the PvAldolase-specific clone was A4–P4. All FR regions are shown by orange bar. The CDR regions are shown by red box. The canonical cysteine residues in FR1 and FR3 regions are highlighted in green. The non-canonical cysteine residues in CDR1 and CDR3 regions are highlighted in yellow background. The mutation sites in FR3 region of clone H8 is highlighted in pink background