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Table 1 SNPs in autophagy-related genes from the Tracking Resistance to Artemisinin Collaboration (TRAC) study

From: A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

Gene Annotation Protein Position Amino acid change Mutation type p value Phenotype
PF3D7_1343700 Kelch protein K13 Kelch13 1,725,259 X N 4E−26 Parasite clearance half-life
PF3D7_1012900 Autophagy-related protein 18 (Atg18), putative Atg18 497,461 T38I N 5.89E−07 Parasite clearance half-life
PF3D7_1239800 Conserved Plasmodium protein, unknown function Atg11 1,669,294 D2948E N 3.92E−05 Parasite clearance half-life
PF3D7_1012900 Autophagy-related protein 18 (Atg18), putative Atg18 497,461 T38I N 0.0002 Chloroquine IC50
PF3D7_1239800 Conserved Plasmodium protein, unknown function Atg11 1,670,910 N3487S N 0.0002 Parasite clearance half-life
PF3D7_0709400 Cg7 protein Atg14 426,753 V161E N 0.0007 Chloroquine IC50
PF3D7_1239800 Conserved Plasmodium protein, unknown function Atg11 1,674,565 N4705K N 0.0007 Piperaquine IC50
PF3D7_1126100 ThiF family protein, putative Atg7 1,018,965 1177C S 0.0044 Chloroquine IC50
PF3D7_1126100 ThiF family protein, putative Atg7 1,018,965 1177C S 0.0129 Quinine IC50
  1. Proteins listed are putative proteins as annotated by PlasmoDB or through BLAST searches. Kelch13 has been included as a reference, since polymorphisms in this gene have been previously associated with drug resistance phenotypes. The amino acid change for Kelch13 is denoted as “X” to represent several different SNPs that have been found within this gene. Mutation types “N” and “S” indicate non-synonymous and synonymous mutations, respectively. The p values are unadjusted for multiple comparisons. All SNPs that associated with long parasite clearance half-life in the TRAC study were published by Miotto et al. [6]