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Table 2 Demographic and clinical data

From: Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance

Patient characteristic P. falciparum (n = 49)
Age, years
 Median (IQR) 18 (11–31)
 Range 3–62
Children (age ≤ 12 years), n (% total) 14 (29)
Male gender, n (%) 38 (78)
Previous malaria (self-reported), n (%) 7 (14)
History of chronic disease, n (%) 0 (0)
Days of fever, median (IQR) 5 (3–6)
Symptoms on enrolment, n (%)
 Rigors/chills 33 (67)
 Headache 45 (92)
 Vomiting 24 (49)
 Abdominal pain 15 (31)
 Diarrhoea 6 (12)
 Cough 16 (33)
 Shortness of breath 5 (10)
 Myalgia 21 (43)
 Arthralgia 22 (45)
Examination findings on enrolment
 Temperature, °C, median (IQR) 37.3 (37.0–38.2)
 Fever, temp ≥ 37.5 °C, n (%) 20 (41)
 Systolic blood pressure, mmHg, median (IQR) 111 (99–120)
 Heart rate, beats/min, median (IQR) 96 (83–106)
 Respiratory rate, breaths/min, median (IQR) 22 (20–24)
 Oxygen saturation, %, median (IQR) 99 (98–100)
 Palpable liver, n (%) 11 (22)
 Palpable spleen, n (%) 5 (10)
 Rash, n (%)  
Laboratory findings on enrolment
 Parasite count, parasites/μL, median (IQR) 9924 (3466–24,276)
 Parasite count, parasites/μL, range 1459–56,789
 Parasite count, parasites/μL, geometric mean (95% CI) 9463 (6757–13,254)
 Ring proportion, mean  % (SD) 89 (0.24)
 Haemoglobin, g/dL, median (IQR) 12.3 (11.0–13.9)
 Anemia (baseline), n (%)* 24 (49)
 G6PD deficiency present, n/N (%) 1/38 (97)
 White blood cell count, × 103/μL, median (IQR) 6.9 (5.6–8.9)
 Neutrophil count, × 103/μL, median (IQR) 4.1 (2.5–6.0)
 Platelet count, × 103/μL, median (IQR) 122 (57–190)
 Thrombocytopenia (platelets < 150 × 103/μL), n (%) 30 (61)
 Creatinine, μmol/L, median (IQR) 69 (50–82)
 Urea, mmol/L, median (IQR) 4.6 (3.3–5.8)
 Bilirubin, μmol/L, median (IQR) 14.6 (9.3–24.0)
 Glucose, mmol/L, median (IQR) 6.3 (5.5–7.1)
 Albumin, g/dL, median (IQR) 34 (28–37)
 ALT, IU/L, median (IQR) 30 (20–45)
 Bicarbonate, mmol/L, median (IQR) 20.9 (20.0–22.8)
 Acute kidney injury, n (%) 3 (6)
 Blood cultures positive, n (%) 0/29 (0)
  1. * Anemia based on WHO 2011 haemoglobin measurement criteria [20]: age 6–59 months (≤ 100g/dL), 5–11 years (< 115g/dL), 12–14 years (< 120g/dL), non-pregnant women ≥ 15 years (< 120g/dL), pregnant women (< 110g/dL), men ≥ 15 years (< 130g/dL)
  2. Excluding results positive for skin contaminants