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Table 4 Prevalence of the parasites with pfdhfr/pfdhps quintuple and sextuple mutation in 2004–2006 and 2009–2012

From: Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia

Number of mutation* 2004–2006 2009–2012 P-value**
n % n %
  Kalimantan (n = 36) Kalimantan (n = 78)  
≥ 5 31 86.1 57 73.1 0.153
< 5 5 13.9 21 26.9  
  Lombok (n = 45) Lombok (n = 48)  
≥ 5 3 6.7 0 0 0.109
< 5 42 93.3 48 100  
  Papua (n = 9) Papua (n = 46)  
≥ 5 0 0 4 8.7 1
< 5 9 100 42 91.3  
  1. * Quintuple, sextuple mutants are parasites containing five or six mutations in the pfdhfr/pfdhps combined haplotype. In this case, pfdhps 588F is included for counting number of mutation
  2. ** P-values were calculated by comparing actual number of patients presenting each genotype by Fisher’s Exact test