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Table 1 Summary of CCp/LAP expression and phenotype in Plasmodium

From: Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes

  P. berghei/P. yoelii P. falciparum
Accession no. Subcellular localization Function or KO phenotype Subcellular localization Function or KO phenotype
CryPH PBANKA_0704900 Crystalloid body CryPH is dispensable for ookinete, oocyst, sporozoite formation ND ND
PfCCp1/PbLAP2 PBANKA_1300700 Gametocyte cytoplasm and crystalloid body in ookinetes [26] LAP2 knockout parasites form oocysts in the normal number, but fail to produce sporozoites inside [35] Female gametocyte surface (punctate pattern) [31]  
PfCCp2/PbLAP4 PBANKA_1319500 Crystalloid body in developing ookinetes [27] LAP4 is essential for oocyst maturation and sporozoite formation [35] Female gametocyte surface (punctate pattern) [31] In CCp2 deficient parasites, oocyst formation is normal but sporozoites were unable to invade salivary glands [29]
PfCCp3/PbLAP1 (PbSR) PBANKA_1035200 Crystalloid body in developing ookinetes [14] PbSR is involved in crystalloid formation. It is dispensable for the oocyst formation but essential for sporozoite formation inside [14, 33] Female gametocyte surface (punctate pattern) [31] CCp3 deficient mutant lacks CCp1 and CCp2. Sporozoites form normally in oocysts, however they lost abilities of release into hemocoel and invasion of salivary glands [29]
PfCCp4/PbLAP6 PBANKA_0417600 Crystalloid body in developing ookinetes [27] LAP6 is essential for oocyst maturation and sporozoite formation [35] Female gametocyte surface (homogenous expression) [31] Co-localized with Pfs230 CCp4 is dispensable for parasite development in the mosquito vector [31]
PfCCp5/PbLAP3 PBANKA_0204500 Gametocyte cytoplasm and crystalloid body in ookinetes [26] LAP3 is essential for crystalloid body formation, and for oocyst maturation to produce sporozoites [67] Female gametocytes (at the pole) [31]  
PfFNPA/PbLAP5 PBANKA_1315300 Crystalloid body in developing ookinetes [27] LAP5 knockout parasites form oocysts in the normal number, but fail to produce sporozoites inside [36] Female gametocytes (at the pole) [31]  
  1. Carter et al. [14], Saeed et al. [26, 27], Pradel et al. [29], Scholz et al. [31], Claudianos et al. [33], Raine et al. [35], Ecker et al. [36], Saeed et al. [67] 2015
  2. ND not done