Skip to main content

Advertisement

Table 2 Magnitude and prevalence of antibodies and IgG responses in parasitaemic and aparasitaemic children at 18 months

From: The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

Antigen tested/parasite isolate Median antibody levela (IQRb) Number of seropositivec children (%) p valued
All children; (n = 601) Parasitaemic children; (n = 60) Aparasitaemic children; (n = 541)
MSP1 19kDe 2.80 (0.65, 7.09) 12.31 (4.38, 28.79) 2.37 (0.56, 6.08) <0.0001
327 (54.4) 53 (88.3) 274 (50.7) < 0.0001
MSP2f 2.91 (0.87, 9.04) 15.14 (3.47, 35.16) 2.62 (0.79, 7.28) < 0.0001
162 (26.9) 36 (60.0) 126 (23.3) < 0.0001
EBA175g 3.38 (1.95, 16.09) 5.89 (2.89, 21.37) 3.24 (1.92, 15.89) 0.0228
69 (11.5) 15 (25.0) 54 (9.9) 0.001
Rh2A9h 7.17 (2.1, 25.3) 8.59 (3.28, 19.24) 7.11 (4.05, 13.27) 0.5630
151 (25.1) 23 (38.3) 128 (23.7) 0.013
Schizont 3.30 (1.27, 8.09) 17.31 (5.22, 48.66) 2.95 (1.09, 6.98) < 0.0001
325 (54.1) 58 (96.7) 267 (49.4) < 0.0001
E8Bi 0 (0, 0.20) 0.15 (0, 0.86) 0 (0, 0.16) < 0.0001
43 (7.2) 9 (15.0) 34 (6.3) 0.013
R29i 0 (0, 0.07) 0 (0, 1.12) 0 (0, 0.002) < 0.0001
21 (3.5) 9 (15.0) 12 (2.2) < 0.0001
3D7i 0 (0, 0.35) 0.30 (0, 2.08) 0 (0, 0.29) < 0.0001
50 (8.3) 17 (28.3) 33 (6.1) < 0.0001
  1. Significant p value in italic format
  2. aAntibody levels expressed as units relative to positive control
  3. bInterquartile range
  4. cSamples defined as antibody positive if levels greater than mean + 3SD of negative controls
  5. dp value between parasitaemic and aparasitaemic children calculated by Mann–Whitney test or Chi squared test for antibody level or seropositivity, respectively
  6. eMerozoite surface protein 1
  7. fMerozoite surface protein 2
  8. gErythrocyte binding antigen 175
  9. hReticulocyte binding protein homologue 2A
  10. iVariant surface antigen antibody responses