Fig. 1

CD spectra in H₂O of PvRON2-based peptides in the presence of H₂O and TFE/H₂O (1:1). The conformational properties of PvRON2-based peptides were examined by CD in an aqueous solution containing the structure-inducing solvent TFE. In water, both peptides presented a mixture of PPII and random coil conformations. a For the cyclic peptide, this conformation changed in the presence of TFE/H₂O (1:1) to a 3₁₀ helix conformation with α-helices contributions. b For the linear peptide, this conformation changed in the presence of TFE/H₂O (1:1) to a predominantly α-helical conformation