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Table 1 Highly conserved motifs in Class I aaRS

From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

  Motif 1 Motif 2 Motif 6 Motif 12 Motif 20 Motif 65
PfArgRS 134–152
HsArgRS 197–215
PfCysRS 131–149 382–419
HsCysRS 53–71 405–442 700–714
PfGlnRS 284–302
HsGlnRS 266–284
PfGluRS 313–331
HsGluRS 200–218
PfIleRS 127–145 782–819 623–651 222–271 167–181 91–111
HsIleRS 44–62 599–636 444–472 139–188 94–108 63–83
PfLeuRS 141–159 1119–1156 688–716 219–268 181–195 160–180
HsLeuRS 49–67 715–752 89–103
PfMetRS 228–246 514–551 268–282 247–267
HsMetRS 269–287 310–324 289–309
PfTrpRS 306–324 534–548
HsTrpRS 159–177
PfTyrRS 61–79
HsTyrRS 53–71
PfValRS 86–104 628–665 454–482 181–230 126–140 105–125
HsValRS 340–358 861–898 708–736 435–484 380–394 359–379
  1. Motif 1, 2, 6, 12, 20 and 65 in Class I Plasmodium falciparum aaRS and the human homologues. Motif positions in the sequences are indicated and dashes are used where the motif is not present