Table 1 Highly conserved motifs in Class I aaRS
From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study
| Â | Motif 1 | Motif 2 | Motif 6 | Motif 12 | Motif 20 | Motif 65 |
|---|---|---|---|---|---|---|
PfArgRS | 134–152 | – | – | – | – | – |
HsArgRS | 197–215 | – | – | – | – | – |
PfCysRS | 131–149 | 382–419 | – | – | – | – |
HsCysRS | 53–71 | 405–442 | – | – | 700–714 | – |
PfGlnRS | 284–302 | – | – | – | – | – |
HsGlnRS | 266–284 | – | – | – | – | – |
PfGluRS | 313–331 | – | – | – | – | – |
HsGluRS | 200–218 | – | – | – | – | – |
PfIleRS | 127–145 | 782–819 | 623–651 | 222–271 | 167–181 | 91–111 |
HsIleRS | 44–62 | 599–636 | 444–472 | 139–188 | 94–108 | 63–83 |
PfLeuRS | 141–159 | 1119–1156 | 688–716 | 219–268 | 181–195 | 160–180 |
HsLeuRS | 49–67 | 715–752 | – | – | 89–103 | – |
PfMetRS | 228–246 | 514–551 | – | – | 268–282 | 247–267 |
HsMetRS | 269–287 | – | – | – | 310–324 | 289–309 |
PfTrpRS | 306–324 | – | – | – | 534–548 | – |
HsTrpRS | 159–177 | – | – | – | – | – |
PfTyrRS | 61–79 | – | – | – | – | – |
HsTyrRS | 53–71 | – | – | – | – | – |
PfValRS | 86–104 | 628–665 | 454–482 | 181–230 | 126–140 | 105–125 |
HsValRS | 340–358 | 861–898 | 708–736 | 435–484 | 380–394 | 359–379 |