Table 3 Starting and ending positions of motifs identified in PfArgRS, PfMetRS, PfTrpRS, PfTyrRS, PfLysRS and PfProRS as well as the human homologues
From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study
| Â | Motif 1 | Motif 2 | Motif 3 | Motif 4 | Motif 5 | Motif 6 | Motif 7 | Motif 8 | Motif 9 | Motif 10 | Motif 11 | Motif 12 | Motif 13 | Motif 14 | Motif 15 | Motif 16 | Motif 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PfArgRS | 135–184 | 441–490 | 308–357 | 506–555 | 364–413 | 30–64 | 230–279 | 70–119 | 186–226 | – | – | – | 15–29 | 558–578 | 420–434 | 286–306 | – |
HsArgRS | 198–247 | 499–548 | 371–420 | 568–617 | 428–477 | 101–135 | 293–342 | 142–191 | 249–289 | 50–99 | 620–660 | 8–48 | 346–360 | 478–498 | 549–563 | – | 363–370 |
PfMetRS | 243–292 | 519–559 | – | 439v459 | 331–360 | – | – | 193–242 | 405–433 | – | – | 562–611 | – | 468–517 | 301–329 | – | 657–706 |
HsMetRS | 285–334 | 598–638 | – | 510–530 | 711–740 | – | 460–509 | 234–283 | 35–63 | – | – | 104–153 | 159–208 | – | 343–371 | 839–888 | – |
PfTrpRS | 301–350 | 447–496 | 512–561 | 249–298 | 392–441 | 562–611 | – | 74–123 | – | 124–173 | 1–41 | 203–243 | – | 43–71 | 354–368 | 612–626 | 174–199 |
HsTrpRS | 154–203 | 304–353 | 354–403 | 102–151 | 247–296 | 404–453 | 48–97 | – | – | – | 222–242 | – | 6–46 | – | 206–220 | 454–468 | – |
PfTyrRS | 172–221 | 60–88 | 265–314 | 320–360 | 91–108 | – | 116–144 | – | – | 223–251 | – | – | 30–50 | 149–169 | 254–264 | 362–469 | 51–58 |
HsTyrRS | 150–199 | 39–67 | 240–289 | 295–335 | 69–86 | 488–528 | 97–125 | 395–444 | 339–388 | 200–228 | 447–487 | 1–29 | 129–149 | – | 229–239 | 89–96 | 30–37 |
PfLysRS | 304–353 | 465–514 | 532–581 | 177–226 | 254–303 | 121–170 | 360–409 | 70–119 | 414–463 | 228–248 | – | 515–529 | 40–60 | – | – | 354–359 | – |
HsLysRS | 297–346 | 459–508 | 526–575 | 169–218 | 247–296 | 114–163 | 353–402 | 63–112 | 409–458 | 221–241 | – | 509–523 | 577–597 | – | – | 347–352 | 1–15 |
PfProRS | 362–411 | 268–317 | 662–711 | 502–551 | 570–606 | 447–496 | 319–359 | – | – | – | 718–746 | – | – | 418–446 | 615–648 | – | 109–149 |
HsProRS | 1124–1173 | 1030–1079 | 332–381 | 1266–1315 | 1338–1374 | 1209–1258 | 1081–1121 | 447–496 | 666–715 | 392–441 | 1484–1512 | 191–240 | 257–306 | 1180–1208 | 1383–1416 | 1443–1483 | 497–537 |