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Table 5 Final model accuracy and precision per study site at individual level

From: Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

Study sites Observations (patients) MPE (CI95%) (%) RMSE (%)
Tanzania site no 1 24 (18) − 5 (− 9 to − 1) 12
Kenya site no 2 188 (123) 0 (− 2 to 2) 14
Burkina Faso site no 3 158 (110) 0 (− 2 to 2) 13
Burkina Faso site no 4 78 (55) 2 (− 4 to 8) 30
Tanzania site no 5 68 (52) 0 (− 4 to 2) 14
Tanzania site no 6 22 (20) − 4 (− 7 to − 2) 9
  1. MPE, mean prediction error, calculated as: exp(mean(ln(IPRED/DV)))−1; RMSE, root mean square error, calculated as exp(sqrt(mean(ln(IPRED/DV))2))−1. IPRED and DV represent the individual predicted and observed concentration, respectively