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Table 5 Final model accuracy and precision per study site at individual level

From: Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

Study sites

Observations (patients)

MPE (CI95%) (%)

RMSE (%)

Tanzania site no 1

24 (18)

− 5 (− 9 to − 1)

12

Kenya site no 2

188 (123)

0 (− 2 to 2)

14

Burkina Faso site no 3

158 (110)

0 (− 2 to 2)

13

Burkina Faso site no 4

78 (55)

2 (− 4 to 8)

30

Tanzania site no 5

68 (52)

0 (− 4 to 2)

14

Tanzania site no 6

22 (20)

− 4 (− 7 to − 2)

9

  1. MPE, mean prediction error, calculated as: exp(mean(ln(IPRED/DV)))−1; RMSE, root mean square error, calculated as exp(sqrt(mean(ln(IPRED/DV))2))−1. IPRED and DV represent the individual predicted and observed concentration, respectively
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Malaria Journal

ISSN: 1475-2875

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