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Table 3 A summary of physicochemical properties of FP-2 and FP-3 and homologs partial zymogen sequences

From: Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

Protein Aromaticity GRAVY Instability index Mwgta pIa
Complex Catalytic Complex Catalytic
FP-2 0.12 − 0.59 40.31 38,021.06 27,176.69 6.50 4.94
FP-3 0.14 − 0.53 33.90 38,029.91 27,348.62 5.47 4.72
VP-2 0.14 − 0.40 23.78 37,941.11 27,388.93 5.49 4.74
VP-3 0.14 − 0.47 28.92 38,405.76 28,088.95 5.60 5.00
KP-2 0.14 − 0.54 29.55 38,583.83 27,947.73 5.69 4.93
KP-3 0.14 − 0.51 23.16 38,284.39 27,685.36 5.89 5.13
BP-2 0.14 − 0.52 39.73 38,014.94 27,367.90 5.44 4.77
CP-2 0.13 − 0.47 52.14 37,883.92 27,140.51 5.14 4.54
YP-2 0.14 − 0.46 40.05 38,120.25 27,454.06 5.66 4.78
Cat-K 0.10 − 0.62 33.12 34,566.05 23,495.47 8.83 8.92
Cat-L 0.13 − 0.70 38.17 35,074.20 24,298.86 5.33 4.64
Cat-S 0.12 − 0.56 37.20 34,986.63 23,963.97 8.44 7.64
  1. aSignificant variation between partial zymogen and catalytic sequence
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