Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design

Table 3 A summary of physicochemical properties of FP-2 and FP-3 and homologs partial zymogen sequences

Protein	Aromaticity	GRAVY	Instability index	Mwgt^a		pI^a
Protein	Aromaticity	GRAVY	Instability index	Complex	Catalytic	Complex	Catalytic
FP-2	0.12	− 0.59	40.31	38,021.06	27,176.69	6.50	4.94
FP-3	0.14	− 0.53	33.90	38,029.91	27,348.62	5.47	4.72
VP-2	0.14	− 0.40	23.78	37,941.11	27,388.93	5.49	4.74
VP-3	0.14	− 0.47	28.92	38,405.76	28,088.95	5.60	5.00
KP-2	0.14	− 0.54	29.55	38,583.83	27,947.73	5.69	4.93
KP-3	0.14	− 0.51	23.16	38,284.39	27,685.36	5.89	5.13
BP-2	0.14	− 0.52	39.73	38,014.94	27,367.90	5.44	4.77
CP-2	0.13	− 0.47	52.14	37,883.92	27,140.51	5.14	4.54
YP-2	0.14	− 0.46	40.05	38,120.25	27,454.06	5.66	4.78
Cat-K	0.10	− 0.62	33.12	34,566.05	23,495.47	8.83	8.92
Cat-L	0.13	− 0.70	38.17	35,074.20	24,298.86	5.33	4.64
Cat-S	0.12	− 0.56	37.20	34,986.63	23,963.97	8.44	7.64

ISSN: 1475-2875