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Table 4 Placental pathology by preterm/term and AGA/SGA categories

From: Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso

Placental pathology n/N (%)a n Term Preterm Relative risk (95% CI) P Adjusted relative risk (95% CI) P badj
Acute malaria 181 10/150 (6.7) 2/31 (6.5) 0.97 (0.26; 3.62) 0.97 0.99 (0.27; 3.66) 0.99
Chronic malaria 181 35/150 (23.3) 13/31 (41.9) 2.00 (1.06; 3.78) 0.039 1.49 (0.75; 2.94) 0.26
Past malaria 181 81/150 (54.0) 15/31 (48.4) 0.83 (0.44; 1.58) 0.57 1.08 (0.56; 2.08) 0.82
Chorioamnionitis grade 3 179 11/148 (7.4) 2/31 (6.5) 0.88 (0.23; 3.32) 0.85 1.00 (0.25; 4.00) 0.99
Chorioamnionitis grades 2 and 3 179 67/148 (45.3) 13/31 (41.9) 0.89 (0.46; 1.72) 0.73 0.96 (0.49; 1.87) 0.90
Placental pathology n/N (%)a n AGA SGA Relative risk (95% CI) P Adjusted relative risk (95% CI) P badj
Acute malaria 179 7/115 (6.1) 5/64 (7.8) 1.18 (0.58; 2.39) 0.66 1.03 (0.53; 1.99) 0.94
Chronic malaria 179 30/115 (26.1) 17/64 (26.6) 1.02 (0.65; 1.59) 0.95 0.80 (0.50; 1.27) 0.32
Past malaria 179 63/115 (54.8) 32/64 (50.0) 0.88 (0.60; 1.31) 0.54 1.06 (0.71; 1.57) 0.80
Chorioamnionitis grade 3 177 9/114 (7.9) 4/63 (6.3) 0.86 (0.37; 1.99) 0.70 1.02 (0.45; 2.27) 0.97
Chorioamnionitis grades 2 and 3 177 54/114 (47.4) 26/63 (41.3) 0.85 (0.57; 1.28) 0.43 1.04 (0.70; 1.54) 0.86
  1. AGA appropriate for gestational age, SGA small for gestational age
  2. aAcute: only parasites and minimal hemozoin deposition in the macrophages but not fibrin; Chronic: parasites and Hemozoin deposition; Past: hemozoin usually mixed with fibrin but no parasites. Severity of acute chorioamnionitis and funiculitis (acute histologic chorioamnionitis) was graded histologically as early (grade 1), intermediate (grade 2) and advanced (grade 3) following the Redline-classification [17, 18]
  3. bAdjusted for birth month