Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

Table 5 Comparison of IgG levels in NCIG and CAIG

	Comparison of IgG level in NCIG and CAIG			Age			ERE^a
	Coef.	p	CI 95%	Coef.	p	CI 95%	Coef.	p	CI 95%
IgG1 to AMA1	0.82	0.005	[0.25,1.40]	0.10	< 0.001	[0.06,0.15]	0.08	< 0.001	[0.04,0.13]
IgG1 to MSP1	0.47	0.129	[− 0.13,1.07]	0.11	< 0.001	[0.06,0.16]	0.15	< 0.001	[0.10,0.19]
IgG1 to MSP2 3D7	0.46	0.112	[− 0.11,1.04]	0.10	< 0.001	[0.05,0.15]	0.14	< 0.001	[0.09,0.18]
IgG1 to MSP2 FC27	0.59	0.042	[0.02,1.16]	0.09	< 0.001	[0.04,0.14]	0.12	< 0.001	[0.07,0.16]
IgG1 to MSP3	0.50	0.013	[0.10,0.91]	0.04	0.004	[0.01,0.07]	0.04	0.011	[0.009,0.07]
IgG1 to GLURP R0	0.20	0.361	[− 0.23,0.64]	0.02	0.177	[− 0.23,0.64]	0.024	0.154	[− 0.09,0.06]
IgG1 to GLURP R2	0.36	0.163	[− 0.14,0.86]	0.04	0.026	[0.005,0.08]	0.09	< 0.001	[0.05,0.13]
IgG3 to AMA1	0.78	0.003	[0.27,1.29]	0.09	< 0.001	[0.06,0.14]	0.11	< 0.001	[0.07,0.15]
IgG3 to MSP1	0.81	0.003	[0.27,1.36]	0.07	0.003	[0.02,0.12]	0.16	< 0.001	[0.11,0.20]
IgG3 to MSP2 3D7	0.57	0.067	[− 0.04,1.18]	0.15	< 0.001	[0.10,0.19]	0.11	< 0.001	[0.07,0.16]
IgG3 to MSP2 FC27	0.66	0.023	[0.09,1.24]	0.14	< 0.001	[0.09,0.19]	0.13	< 0.001	[0.08,0.17]
IgG3 to MSP3	0.64	0.002	[0.23,1.05]	0.05	0.002	[0.019,0.08]	0.07	< 0.001	[0.04,0.10]
IgG3 to GLURP R0	0.16	0.426	[− 0.23,0.55]	0.03	0.034	[0.002,0.06]	0.06	< 0.001	[0.03,0.09]
IgG3 to GLURP R2	0.53	0.021	[0.08,0.98]	0.06	0.003	[0.02,0.09]	0.10	< 0.001	[0.06,0.14]

Multivariate analyses (linear mixed models) were performed to compare the difference of Ab mean level between both groups taking into account the Ab measurements at 6, 12, 15 and 18 months of age
Models were adjusted by age and environmental risk. Ab level from CAIG was considered as the reference in the model
Significant p values (p < 0.05) are mentioned in italics
Coef.: coefficient, Coef. > 0: indicate a higher level of Ab from 6 to 18 months of age in CAIG group compared to NCIG group, CI: confidence interval
^aERE represent environmental risk of exposure attributed quarterly for each infant included in the cohort

ISSN: 1475-2875