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Table 2 Baseline characteristics of patients included

From: Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

Baseline characteristics

AL (1996–2014)

ASAQ (2002–2014)

ASMQ (2002–2013)

DP (2002–2013)

Total (1996–2014)

N

16,373

4850

1220

9064

31,507

Gender

 Femalea

7394 (45.2%)

2253 (46.5%)

591 (48.4%)

3464 (38.2%)

13,702 (43.5%)

Age (years)a

 Mean age ± SD (years)

8.3 ± 10.66

7.0 ± 9.21

11.9 ± 13.37

13.5 ± 14.09

9.8 ± 11.94

 < 1 year

924 (5.6%)

312 (6.4%)

65 (5.3%)

386 (4.3%)

1687 (5.4%)

 1 to < 5 years

8629 (52.7%)

2895 (59.7%)

522 (42.8%)

3736 (41.2%)

15,782 (50.1%)

 5 to < 12 years

3306 (20.2%)

773 (15.9%)

201 (16.5%)

1264 (13.9%)

5544 (17.6%)

 ≥ 12 years

3491 (21.3%)

862 (17.8%)

426 (34.9%)

3665 (40.4%)

8444 (26.8%)

 Missing

23 (0.1%)

8 (0.2%)

6 (0.5%)

13 (0.1%)

50 (0.2%)

Continenta

 Africa

14,087 (86.0%)

4550 (93.8%)

810 (66.4%)

4862 (53.6%)

24,309 (77.2%)

 Asia

2127 (13.0%)

300 (6.2%)

410 (33.7%)

3950 (43.6%)

6787 (21.5%)

 South America

159 (1.0%)

0 (0.0%)

0 (0.0%)

252 (2.8%)

411 (1.3%)

Enrolment clinical parameters

 Mean body weight ± SD (kg)

20.9 ± 16.29

20.0 ± 16.02

23.7 ± 17.2

22.4 ± 17.55

21.2 ± 16.63

 Mean haemoglobin ± SD (g/dL)

10.2 ± 2.21

9.6 ± 1.98

10.4 ± 2.26

10.2 ± 2.31

10.1 ± 2.22

 Median parasitaemia [IQR] (/µL)

19,674 [5590–50,550]

21,730 [7353–53,439]

23,386 [5953–64,103]

14,320 [4178–43,337]

18,576 [5284–49,520]

 Elevated temperature (> 37.5°)

64.3% [9705/15,101]

67.9% [3221/4747]

74.0% [743/1004]

60.2% [4200/6972]

64.2% [17,869/27,824]

  1. AL artemether–lumefantrine, ASAQ artesunate–amodiaquine, ASMQ artesunate–mefloquine, DP dihydroartemisinin–piperaquine, IQR interquartile range, SD standard deviation, N number of patients
  2. aColumn percentages presented in parenthesis