| |
Observed proportion of events
|
Cause-specific Cox proportional hazard model
|
Fine and Gray’s sub-distribution hazard model
|
|---|
|
Cause-specific HR [95% confidence interval]
|
P-value
|
Sub-distribution HR [95% confidence interval]
|
P-value
|
|---|
|
Model for recrudescence
|
|
Age (/yearly increase)
|
4.9% (40/810)
|
0.99 [0.77–1.29]
|
0.965
|
1.00 [0.80–1.25]
|
0.990
|
|
Baseline parasitaemia (/µL) (tenfold increase)
|
4.9% (40/810)
|
1.67 [0.88–3.16]
|
0.114
|
1.44 [0.84–2.46]
|
0.190
|
|
Treatment (ref = DP)
|
3.2% (7/221)
| | | | |
|
AL
|
8.2% (24/294)
|
4.02 [1.72–9.43]
|
0.001
|
2.85 [1.24–6.57]
|
0.014
|
|
ASAQ
|
3.1% (9/295)
|
1.12 [0.42–2.99]
|
0.829
|
1.01 [0.38–2.69]
|
0.980
|
|
Model for new infection
|
|
Age (/yearly increase)
|
29.4% (238/810)
|
1.08[0.98–1.21]
|
0.121
|
1.08[0.99–1.19]
|
0.093
|
|
Baseline parasitaemia (/µL) (tenfold increase)
|
29.4% (238/810)
|
1.52[1.18–1.97]
|
0.001
|
1.40[1.10–1.78]
|
0.006
|
|
Treatment (ref = DP)
|
10.0% (22/221)
| | | | |
|
AL
|
48.3% (142/294)
|
8.05[5.12–12.67]
|
< 0.001
|
6.51[4.27–9.94]
|
< 0.001
|
|
ASAQ
|
25.1% (74/295)
|
3.03[1.88–4.88]
|
< 0.001
|
2.83[1.80–4.44]
|
< 0.001
|
- AL artemether–lumefantrine, DP dihydroartemisinin–piperaquine, ASAQ artesunate–amodiaquine
