Table 5 Regression models for recrudescence and new infection using data from Burkina Faso (n = 810) [18]
Observed proportion of events | Cause-specific Cox proportional hazard model | Fine and Gray’s sub-distribution hazard model | |||
|---|---|---|---|---|---|
Cause-specific HR [95% confidence interval] | P-value | Sub-distribution HR [95% confidence interval] | P-value | ||
Model for recrudescence | |||||
Age (/yearly increase) | 4.9% (40/810) | 0.99 [0.77–1.29] | 0.965 | 1.00 [0.80–1.25] | 0.990 |
Baseline parasitaemia (/µL) (tenfold increase) | 4.9% (40/810) | 1.67 [0.88–3.16] | 0.114 | 1.44 [0.84–2.46] | 0.190 |
Treatment (ref = DP) | 3.2% (7/221) | ||||
AL | 8.2% (24/294) | 4.02 [1.72–9.43] | 0.001 | 2.85 [1.24–6.57] | 0.014 |
ASAQ | 3.1% (9/295) | 1.12 [0.42–2.99] | 0.829 | 1.01 [0.38–2.69] | 0.980 |
Model for new infection | |||||
Age (/yearly increase) | 29.4% (238/810) | 1.08[0.98–1.21] | 0.121 | 1.08[0.99–1.19] | 0.093 |
Baseline parasitaemia (/µL) (tenfold increase) | 29.4% (238/810) | 1.52[1.18–1.97] | 0.001 | 1.40[1.10–1.78] | 0.006 |
Treatment (ref = DP) | 10.0% (22/221) | ||||
AL | 48.3% (142/294) | 8.05[5.12–12.67] | < 0.001 | 6.51[4.27–9.94] | < 0.001 |
ASAQ | 25.1% (74/295) | 3.03[1.88–4.88] | < 0.001 | 2.83[1.80–4.44] | < 0.001 |