Skip to main content

Advertisement

Table 1 Pharmacokinetic analysis of P. chabaudi AS-infected mice

From: A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Drug AUC Clearance
Naïve PccAS Naïve PccAS
mM h mM h L/h L/h
Caffeine 1.11 ± 0.40 2.97 ± 0.95 109 ± 68 36 ± 11
Bupropion 0.112 ± 0.26 0.391 ± 0.127 934 ± 212 280 ± 98***
Tolbutamide 10.0 ± 1.9 48.5 ± 54.2 10.3 ± 2.1 4.2 ± 2.9*
Midazolam 33.6 ± 26.9 97.9 ± 76.0 4.04 ± 1.77 1.38 ± 0.61
  1. *P < 0.05, ***P < 0.001 compared to naïve animals using MANOVA and post hoc analysis using a general linear model with Bonferroni correction. AUC values were not tested for significance