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Table 1 Pharmacokinetic analysis of P. chabaudi AS-infected mice

From: A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice

Drug

AUC

Clearance

Naïve

PccAS

Naïve

PccAS

mM h

mM h

L/h

L/h

Caffeine

1.11 ± 0.40

2.97 ± 0.95

109 ± 68

36 ± 11

Bupropion

0.112 ± 0.26

0.391 ± 0.127

934 ± 212

280 ± 98***

Tolbutamide

10.0 ± 1.9

48.5 ± 54.2

10.3 ± 2.1

4.2 ± 2.9*

Midazolam

33.6 ± 26.9

97.9 ± 76.0

4.04 ± 1.77

1.38 ± 0.61

  1. *P < 0.05, ***P < 0.001 compared to naïve animals using MANOVA and post hoc analysis using a general linear model with Bonferroni correction. AUC values were not tested for significance
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Malaria Journal

ISSN: 1475-2875

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