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Table 5 Impact of IPTp on the risk of malaria in infancy

From: Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

Author, year of publication

Randomized

Y/N

IPTp arm (n)

Measure of association (95% CI), p-value

Confounders adjusted for

Ruperez,, 2016 [38]

Yes

IPTp-SP (1432)

Reference

Country

IPTP-MQ (2815)

IRR = 0.95 (0.81–1.13), p = 0.60

Awine, 2016 [19]

Yes

IPTp-SP (495)

Reference

Gender, social economic status, residence, irrigated area, season, ITN use, baseline parasitaemia, maternal haemoglobin

ISTp-AL (493)

IRR = 0.94 (0.68–1.59), p = 0.76

Asante, 2013 [20]

No

IPTp-SP (1755)

Reference

Unadjusted

No IPTp (97)

HR = 1.23 (0.93–1.59), p = 0.15

Bardaji, 2011 [16]

Yes

Placebo (500)

Reference

Unadjusted

IPTp-SP (497)

OR = 1.28 (0.90–1.83), p = 0.17

  1. AL artemether lumefantrine, CI confidence interval, IPTp intermittent preventive treatment of malaria in pregnancy, IRR incident rate ratio, ISTp intermittent screening and treatment of malaria in pregnancy, ITN insecticide treated nets, HR hazard ratio, MQ mefloquine, SP sulfadoxine–pyrimethamine