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Table 3 Proportion of patients with hospitalization and severe malaria according to FY genotypes

From: Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India

 

FYA/FYA

FYA/FYB

FYB/FYB

FYB carriage with DARC 298A carriage

Hospitalizationa

 All species

5.0% (20/399)

3.5% (14/401)

0.9% (1/109)

2.6% (4/152)

 P. vivax

3.6% (10/280)

3.6% (10/277)

1.31% (1/76)

3.6% (4/112)

 P. falciparum

16.7% (6/36)

0% (0/34)*

0% (0/12)

0% (0/13)

 Mixed

4.8% (4/83)

4.4% (4/90)

0% (0/21)

0% (0/27)

Severe malariab

 All species

3.5% (14/399)

3.7% (15/401)

2.8% (3/109)

3.3% (5/152)

 P. vivax

2.9% (8/280)

3.6% (10/277)

2.6% (2/76)

3.6% (4/112)

 P. falciparum

11.1% (4/36)

0% (0/34)

0% (0/12)

0% (0/13)

 Mixed

2.4% (2/83)

5.6% (5/90)

4.8% (1/21)

3.7% (1/27)

  1. aOf 35 patients admitted to ward, 10 were categorized as severe malaria patients. Other reasons included vomiting (5), dehydration (2), co-morbidities (2), weakness (2), suspected typhoid fever (1), jaundice (1), recent delivery (1), patient request (1), low blood pressure (1) as well as retrospectively not ascertainable causes (9)
  2. b32 patients had severe malaria according to the WHO definition, i.e., hypotension (15; impaired perfusion not assessed), renal impairment (5), renal impairment and respiratory distress (1), severe malarial anaemia (4), prostration (3), confusion (2), jaundice (1), and abnormal bleeding (haematemesis, 1). Impaired consciousness, convulsions, hypoglycaemia, acidosis, hyperparasitaemia and pulmonary oedema were not observed
  3. P < 0.05 as compared to FYA/FYA