Table 3 Schizont maturation inhibition (%) and haemolysis of normal erythrocytes (%) with effect to the chalcones
Drugs/compound | % Schizont maturation inhibition ± SD (MRC-2) (Conc. = 6.25 μg/mL) | % Schizont maturation inhibition ± SD (RKL-9) (Conc. = 6.25 μg/mL) | % Hemolysis ± SD (Conc. = 12.5 μg/mL) |
|---|---|---|---|
1 | 82.43 ± 20.51 | 49.66 ± 25.46 | 1.44 ± 0.005 |
2 | 71.76 ± 10.61 | 58.02 ± 21.21 | 0.86 ± 0.002 |
3 | 59.26 ± 4.95 | 63.71 ± 2.83 | 1.01 ± 0.003 |
4 | 47.48 ± 17.68 | 57.69 ± 7.78 | 0.94 ± 0.006 |
5 | 58.65 ± 7.78 | 40 ± 20.51 | 0.65 ± 0.001 |
6 | 51.05 ± 42.42 | 43.85 ± 33.23 | 1.15 ± 0.005 |
7 | 94.24 ± 2.21 | 85.82 ± 6.36 | 1.08 ± 0.001 |
8 | 75.17 ± 12.02 | 77.78 ± 1.41 | 0.83 ± 0.003 |
9 | 50.32 ± 33.23 | 48.87 ± 25.46 | 1.30 ± 0.009 |
10 | 64.44 ± 9.90 | 49.62 ± 19.79 | 1.51 ± 0.013 |
CHL | 88.39 ± 0.71 | – | 0.86 ± 0.001 |
QNN | – | 71.87 ± 16.26 | 2.16 ± 0.035 |
ART (ng/mL) | – | 87.88 ± 2.12 | 1.94 ± 0.026 |