Table 2 Isobologram data and combination profiles of compounds 1–11 with artesunate. Numbers indicate how many FIC50 pairs were located in each isobologram region
Compound | Isobologram data | Combination profile | |||
|---|---|---|---|---|---|
# | MMV code | Antagonistic | Additive | Synergic | |
01 | MMV006172 | 11 (92%) | 1 (8%) | 0 | Antagonism |
02 | MMV665971 | 1 (8%) | 12 (92%) | 0 | Additivity |
03 | MMV007224 | 8 (62%) | 5 (38%) | 0 | Antagonism |
04 | MMV666607 | 12 (92%) | 1 (8%) | 0 | Antagonism |
05 | MMV020439 | 11 (85%) | 2 (15%) | 0 | Antagonism |
06 | MMV665934 | 11 (85%) | 2 (15%) | 0 | Antagonism |
07 | MMV007574 | 7 (78%) | 2 (22%) | 0 | Antagonism |
08 | MMV085203 | 8 (67%) | 4 (33%) | 0 | Antagonism |
09 | MMV085583 | 0 | 13 (100%) | 0 | Additivity |
10 | MMV018984 | 8 (62%) | 5 (38%) | 0 | Antagonism |
11 | MMV019871 | 12 (100%) | 0 | 0 | Antagonism |
Artesunate | 0 | 15 (100%) | 0 | Additivity | |