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Fig. 4 | Malaria Journal

Fig. 4

From: Identification, molecular characterization and expression of aminopeptidase N-1 (APN-1) from Anopheles stephensi in SF9 cell line as a candidate molecule for developing a vaccine that interrupt malaria transmission

Fig. 4

Structural comparison of the AsAPN-1 and AgAPN-1 (as reference molecule). Hydrogen bonds donor and acceptor plot of AsAPN-1 (a) and AgAPN-1 (b) show that the involved residues in creating the hydrogen bonds are very similar in both molecules; Ramachandran plots: the Ramachandran plots of AsAPN-1 and AgAPN-1 were analysed by discovery studio visualizer and revealed that the pattern of AsAPN-1 (our target molecule) (c) is very similar to the AgAPN-1 as the reference molecule (d). Green spots which are enclosed in blue lines, indicate that residues are in the most favored region, while the spots which are located out of the redlines are in the disallowed regions. Stoichiometry analysis of Carbon-α: the stoichiometry analysis of alpha carbons in AsAPN-1 (e) and AgAPN-1 (f) revealed that the topologies of carbons-α in both molecules are very similar. All these results were obtained using the discovery studio visualization software (Version 4.0 Accelrys, San Diego, USA)

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Malaria Journal

ISSN: 1475-2875

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