Table 3 Chloroquine susceptibility in pfcrt haplotypes obtained from sequencing the entire pfcrt gene
pfcrt haplotypes | pfcrt polymorphic positions | Mean chloroquine IC50 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
24 | 34 | 72 | 73 | 74 | 75 | 76 | 220 | 271 | 371 | ||
HP 1 (n = 44) | D | R | C | V | M | N | K | A | Q | R | 18.2 (n = 31) |
HP 2 (n = 4) | Y | R | C | V | M | N | K | A | Q | R | 22.2 (n = 4) |
HP 3 (n = 1) | D | G | C | V | M | N | K | A | Q | R | 19.7 (n = 1) |
HP 4 (n = 5) | D | R | C | V | I | E | T | S | E | I | 22.2 (n = 5) |
HP 5 (n = 2) | D | R | C | V | M | N | K | A | E | R | 35.2 (n = 2) |
HP 6 (n = 1) | D | R | C | V | M | N | K | A | Q | I | 17.5 (n = 1) |