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Table 4 nsSNPs in T- and B-cell epitopes of pvdbp-II

From: Extensive genetic diversity of Plasmodium vivax dbp-II in Rio de Janeiro Atlantic Forest and Brazilian Amazon Basin: evidence of positive selection

Peptide

Residues

Epitope

N (%)

B- and T-cell epitope scores π (SD)

5

299-VNNTDT(N/Y)FH(R/S)DITFR-313

T/B

101 (47)

0.011 (± 0.0010)

13

315-LYLKRKL(I/S)YDAAVEG-329

T

17 (22)

0.003 (± 0.0006)

16

321-LIYDAAVEGDLL(L/F)KL-335

T/B

60 (28)

0.009 (± 0.0005)

20

329-GDLL(L/F)KLNNYRYNKD-343

T/B

59 (27)

0.008 (± 0.0006)

45

379-SIFGT(D/G)(E/K)(K/N) AQQ(R/H)RKQ-393

B

210 (97)

0.051 (± 0.0011)

48

385-(E/K)(K/N)AQQ(R/H)RKQWWNE(S/T)K-399

B

207 (96)

0.047 (± 0.0012)

66

421-ICK(L/I)NVAVNIEPQIY-435

T

152 (70)

0.020 (± 0.0007)

78

445-YVSELPTEV(Q/P)RLKEK-459

B

20 (9)

0.005 (± 0.0009)

  1. Previously identified epitopes in peptides 5, 13, 16, 20, 45, 48, 66 and 78 [16, 17]
  2. N number of isolates, π Nucleotide diversity, the values in italic represents those with median higher than the entire pvdbp-II fragment (π = 0.012) and SD standard deviation calculated for each epitope sequence