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Table 4 nsSNPs in T- and B-cell epitopes of pvdbp-II

From: Extensive genetic diversity of Plasmodium vivax dbp-II in Rio de Janeiro Atlantic Forest and Brazilian Amazon Basin: evidence of positive selection

PeptideResiduesEpitopeN (%)B- and T-cell epitope scores π (SD)
5299-VNNTDT(N/Y)FH(R/S)DITFR-313T/B101 (47)0.011 (± 0.0010)
13315-LYLKRKL(I/S)YDAAVEG-329T17 (22)0.003 (± 0.0006)
16321-LIYDAAVEGDLL(L/F)KL-335T/B60 (28)0.009 (± 0.0005)
20329-GDLL(L/F)KLNNYRYNKD-343T/B59 (27)0.008 (± 0.0006)
45379-SIFGT(D/G)(E/K)(K/N) AQQ(R/H)RKQ-393B210 (97)0.051 (± 0.0011)
48385-(E/K)(K/N)AQQ(R/H)RKQWWNE(S/T)K-399B207 (96)0.047 (± 0.0012)
66421-ICK(L/I)NVAVNIEPQIY-435T152 (70)0.020 (± 0.0007)
78445-YVSELPTEV(Q/P)RLKEK-459B20 (9)0.005 (± 0.0009)
  1. Previously identified epitopes in peptides 5, 13, 16, 20, 45, 48, 66 and 78 [16, 17]
  2. N number of isolates, π Nucleotide diversity, the values in italic represents those with median higher than the entire pvdbp-II fragment (π = 0.012) and SD standard deviation calculated for each epitope sequence