Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Aka, Kakou G.; Traoré, Dipomin F.; Sagna, André B.; Zoh, Dounin D.; Assi, Serge B.; Tchiekoi, Bertin N’cho; Adja, Akré M.; Remoue, Franck; Poinsignon, Anne

doi:10.1186/s12936-020-03160-5

Table 2 Influence of covariate factors on specific IgG, IgG1 and IgG3 antibody levels in children

From: Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Covariate factors	Ab response	Total population	p	Petessou	p	Dar-es-Salam	p
Gender (female/male)^a	IgG anti-PfMSP1	0.16 (0.38;1.12)/0.38 (0.49;1.11)	0.435	0.76 (0.21;2.05)/1.01 (0.19;2.26)	0.835	0.02 (0;0.09)/0.12 (0;0.53)	0.151
	IgG1 anti-PfMSP1	0.14 (0.25;0.92)/0.41 (0.55;1.31)	0.122	0.34 (0.13;1.17)/0.59 (0.30;2.79)	0.07	0.08 (0.01;0.18)/0.13 (0;0.67)	0.58
	IgG3 anti-PfMSP1	0.21 (0.33;0.96)/0.24 (0.40;1.10)	0.322	0.63 (0.24;1.74)/0.65 (0.27;2.70)	0.861	0.00 (0;0.04)/0.03 (0;0.18)	0.065
	IgG anti-PfAMA1	1.02 (0.755;1.563)/0.91 (0.83;1.68)	0.452	1.93 (1.2;2.91)/2.68 (1.28;3.02)	0.506	0.00 (0;0.60)/0.01 (0;0.37)	0.131
	IgG1 anti-PfAMA1	1.19 (1.06;2.15)/0.86 (1.04;2.17)	0.565	3.24 (1.67;3.89)/3.41 (1.86;3.94)	0.758	0.01 (0;0.67)/0.06 (0; 0.58)	0.145
	IgG3 anti-PfAMA1	0.58 (0.55;1.29)/0.37 (0.63;1.49)	0.529	1.15 (0.62;2.34)/1.87 (0.56;3.08)	0.557	0.01 (0; 0.47)/0.034 (0; 0.27)	0.204
Age (years)^b	IgG anti-PfMSP1	0.002	0.280	− 0.001	0.330	− .031	0.888
	IgG1 anti-PfMSP1	− 0.009	0.551	0.018	0.564	− 0.029	0.788
	IgG3 anti-PfMSP1	0.052	0.287	0.068	0.063	− 0.001	0.335
	IgG anti-PfAMA1	0.001	0.316	− 0.014	0.491	− 0.029	0.825
	IgG1 anti-PfAMA1	− 0.010	0.601	− 0.027	0.878	− 0.029	0.823
	IgG3 anti-PfAMA1	0.029	0.077	0.028	0.150	− 0.018	0.539
Group of exposure Anopheles bites (low/high)^a	IgG anti-PfMSP1	0.53 (0.09;1.97)/0.12 (0.01;0.58)	0.016	1.56 (0.76;2.54)/0.27 (0.06;0.67)	0.001	0.07 (0;0.16)/0.02 (0;0.55)	0.944
	IgG1 anti-PfMSP1	0.40 (0.10;1.41)/0.16 (0.04;0.50)	0.034	1.17 (0.40;2.89)/0.18 (0.13;0.48)	0.002	0.10 (0.03;0.27)/0.09 (0;0.87)	1.000
	IgG3 anti-PfMSP1	0.25 (0.05;2.01)/0.11 (0.00;0.48)	0.040	1.29 (0.41;2.72)/0.45 (0.23;1.14)	0.030	0.02 (0; 0.12)/0.01 (0; 0.10)	0.505
	IgG anti-PfAMA1	1.00 (0.04;2.74)/0.80 (0;2.57)	0.345	1.58 (1.17;3.01)/2.50 (1.37;2.88)	0.864	0.03 (0.02;0.14)/0 (0; 0.65)	0.285
	IgG1 anti-PfAMA1	0.78 (0.07;3.26)/0.98 (0.01;3.43)	0.456	2.70 (1.56;3.95)/3.51 (2.54;3.89)	0.368	0.06 (0;04; 0.283)/0.01 (0;0.79)	0.216
	IgG3 anti-PfAMA1	0.79 (0.04;2.62)/0.17 (0.0;1.16)	0.076	2.01 (0.78;3.03)/0.93 (0.50;2.07)	0.124	0.02 (0.0; 0.29)/0.01 (0;0.43)	0.533
Site (Petessou/Dar-es-Salam)^a	IgG anti-PfMSP1	0.80 (0.21;2.20)/0.05 (0;0.22)	< 0.0001
	IgG1 anti-PfMSP1	0.45 (0.18;2.12)/0.09 (0;0.27)	< 0.0001
	IgG3 anti-PfMSP1	0.64 (0.26;1.83)/0.01 (0;0.12)	< 0.0001
	IgG anti-PfAMA1	2.47 (1.25;2.97)/0.01 (0;0.18)	< 0.0001
	IgG1 anti-PfAMA1	3.33 (1.71;3.91)/0.02 (0.01;0.21)	< 0.0001
	IgG3 anti-PfAMA1	1.52 (0.61;2.8)/0.02 (0;0.05)	< 0.0001

^aMedian (25th; 75th percentile)
^bAdjusted R-squared

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