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Table 2 Influence of covariate factors on specific IgG, IgG1 and IgG3 antibody levels in children

From: Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Covariate factorsAb responseTotal populationpPetessoupDar-es-Salamp
Gender (female/male)aIgG anti-PfMSP10.16 (0.38;1.12)/0.38 (0.49;1.11)0.4350.76 (0.21;2.05)/1.01 (0.19;2.26)0.8350.02 (0;0.09)/0.12 (0;0.53)0.151
IgG1 anti-PfMSP10.14 (0.25;0.92)/0.41 (0.55;1.31)0.1220.34 (0.13;1.17)/0.59 (0.30;2.79)0.070.08 (0.01;0.18)/0.13 (0;0.67)0.58
IgG3 anti-PfMSP10.21 (0.33;0.96)/0.24 (0.40;1.10)0.3220.63 (0.24;1.74)/0.65 (0.27;2.70)0.8610.00 (0;0.04)/0.03 (0;0.18)0.065
IgG anti-PfAMA11.02 (0.755;1.563)/0.91 (0.83;1.68)0.4521.93 (1.2;2.91)/2.68 (1.28;3.02)0.5060.00 (0;0.60)/0.01 (0;0.37)0.131
IgG1 anti-PfAMA11.19 (1.06;2.15)/0.86 (1.04;2.17)0.5653.24 (1.67;3.89)/3.41 (1.86;3.94)0.7580.01 (0;0.67)/0.06 (0; 0.58)0.145
IgG3 anti-PfAMA10.58 (0.55;1.29)/0.37 (0.63;1.49)0.5291.15 (0.62;2.34)/1.87 (0.56;3.08)0.5570.01 (0; 0.47)/0.034 (0; 0.27)0.204
Age (years)bIgG anti-PfMSP10.0020.280− 0.0010.330− .0310.888
IgG1 anti-PfMSP1− 0.0090.5510.0180.564− 0.0290.788
IgG3 anti-PfMSP10.0520.2870.0680.063− 0.0010.335
IgG anti-PfAMA10.0010.316− 0.0140.491− 0.0290.825
IgG1 anti-PfAMA1− 0.0100.601− 0.0270.878− 0.0290.823
IgG3 anti-PfAMA10.0290.0770.0280.150− 0.0180.539
Group of exposure Anopheles bites (low/high)aIgG anti-PfMSP10.53 (0.09;1.97)/0.12 (0.01;0.58)0.0161.56 (0.76;2.54)/0.27 (0.06;0.67)0.0010.07 (0;0.16)/0.02 (0;0.55)0.944
IgG1 anti-PfMSP10.40 (0.10;1.41)/0.16 (0.04;0.50)0.0341.17 (0.40;2.89)/0.18 (0.13;0.48)0.0020.10 (0.03;0.27)/0.09 (0;0.87)1.000
IgG3 anti-PfMSP10.25 (0.05;2.01)/0.11 (0.00;0.48)0.0401.29 (0.41;2.72)/0.45 (0.23;1.14)0.0300.02 (0; 0.12)/0.01 (0; 0.10)0.505
IgG anti-PfAMA11.00 (0.04;2.74)/0.80 (0;2.57)0.3451.58 (1.17;3.01)/2.50 (1.37;2.88)0.8640.03 (0.02;0.14)/0 (0; 0.65)0.285
IgG1 anti-PfAMA10.78 (0.07;3.26)/0.98 (0.01;3.43)0.4562.70 (1.56;3.95)/3.51 (2.54;3.89)0.3680.06 (0;04; 0.283)/0.01 (0;0.79)0.216
IgG3 anti-PfAMA10.79 (0.04;2.62)/0.17 (0.0;1.16)0.0762.01 (0.78;3.03)/0.93 (0.50;2.07)0.1240.02 (0.0; 0.29)/0.01 (0;0.43)0.533
Site (Petessou/Dar-es-Salam)aIgG anti-PfMSP10.80 (0.21;2.20)/0.05 (0;0.22)< 0.0001    
IgG1 anti-PfMSP10.45 (0.18;2.12)/0.09 (0;0.27)< 0.0001    
IgG3 anti-PfMSP10.64 (0.26;1.83)/0.01 (0;0.12)< 0.0001    
IgG anti-PfAMA12.47 (1.25;2.97)/0.01 (0;0.18)< 0.0001    
IgG1 anti-PfAMA13.33 (1.71;3.91)/0.02 (0.01;0.21)< 0.0001    
IgG3 anti-PfAMA11.52 (0.61;2.8)/0.02 (0;0.05)< 0.0001    
  1. aMedian (25th; 75th percentile)
  2. bAdjusted R-squared